Thiazole small molecules spark cell differentiation
Andy Whiting et al state that the molecule with the longest, most bulky hydrophobic side chain was found to possess cell-differentiation activity on a level comparable with naturally occurring retinoid ATRA (all-trans-retinoic acid) – a major metabolite of vitamin A that is involved in many important biological pathways.
Whiting’s group also studied the effect of subtle modifications to the molecules’ structure, specifically the bulky side chain. A knowledge of such structure-activity relationships is thought to be crucial to chemists’ ability to design new biologically active compounds.
Original publication
Organizations
Other news from the department science
Get the life science industry in your inbox
From now on, don't miss a thing: Our newsletter for biotechnology, pharma and life sciences brings you up to date every Tuesday and Thursday. The latest industry news, product highlights and innovations - compact and easy to understand in your inbox. Researched by us so you don't have to.