Morphochem announces determination of the X-ray structure of Endothelin Converting Enzyme (ECE-1) complexed with Phosphoramidon

02-Dec-2005

Morphochem AG has announced that they have successfully achieved an important milestone in their research collaboration with Solvay Pharmaceuticals using Morphochem's structural biology tools to support their Endothelin-Converting Enzyme inhibitor program.

Morphochem applied its protein expression, purification, crystallization and structure determination capabilities to generate biostructural information for further optimization of inhibitor compounds against Endothelin-Converting Enzyme.

Commenting on the collaboration, Glenn E. Dale, Head of Biological Sciences at Morphochem said: "We are delighted that Morphochem could rapidly and successfully determine the three-dimensional structure of ECE-1 complexed with phosphoramidon, thereby providing the necessary tools to Solvay for this very important target."

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