NanoTemper Technologies

Loading...

nanoDSF vs. µDSC: A Comparative Study for Biopharmaceutical Formulation Development

NanoTemper Technologies GmbH

Rapid and Easy Thermal Stability Analysis for Antibody Formulation Development with nanoDSF

The assessment of thermal stability parameters of biologics is an integral part of formulation development in biopharmaceutical research. The ever growing number of biologics in the development pipelines worldwide demands rapid and precise methods to quickly screen large sets of conditions in an easy and straightforward manner. In our study, we compare two methods for the detection of thermal unfolding transition temperatures (Tm) of a therapeutic monoclonal antibody (mAb): nanoDSF, which analyzes changes in the fluorescence emission properties of proteins, and differential scanning calorimetry (µDSC), which detects changes in the heat capacity of a protein solution upon unfolding. nanoDSF and µDSC both provide precise and consistent data. nanoDSF in addition overcomes several limitations by µDSC, such as low throughput and high sample consumption, and thus represents the ideal technology for rapid and precise thermal stability screening in biopharmaceutical development.

Download white paper now

nanoDSF vs. µDSC: A Comparative Study for Biopharmaceutical Formulation Development

Rapid and Easy Thermal Stability Analysis for Antibody Formulation Development with nanoDSF

NanoTemper Technologies GmbH
All about NanoTemper Technologies

You may also be interested in these white papers

Thermal Stability Technology Selection Guide for Biotherapeutic Drug Development

Automated Method Development Using Analytical Quality-byDesign for Stability Indicating Methods

How to purify and analyze your antibodies efficiently

The Diffusion Interaction Parameter (kD) as an Indicator of Colloidal and Thermal Stability

Measurement of secondary structure directly in formulation without interference from excipients

The Diffusion Interaction Parameter (kD) as an Indicator of Colloidal and Thermal Stability

Essential Laboratory Skills Guide