Milestone: Researchers have generated primordial germ cells from stem cells – a world’s first

A big step toward producing rhino gametes

13-Dec-2022 - To save the northern white rhinoceros from extinction, the BioRescue team is racing to create lab-grown egg and sperm cells of the critically endangered subspecies. The team has now reported a milestone in “Science Advances”: they have generated primordial germ cells from stem cells – a world’s ...

Evotec and Sernova announce exclusive strategic partnership for iPSC-based beta cell replacement therapy to advance a 'functional cure' for diabetes

19-May-2022 - Evotec SE and Sernova Corp., a clinical-stage company and leader in regenerative medicine cell therapeutics announced a partnership in the field of diabetes. Both Companies will leverage their respective strengths to develop an implantable iPSC-based beta cell replacement therapy for the ...

A Speed Limit Could Be a Breakthrough for Stem Cell Therapy

Less speed, improved cellular reprogramming

10-Mar-2022 - Replacing sick or damaged cells with healthy cells: this is a major goal of regenerative medicine. One of the most promising approaches is cellular reprogramming, whereby one cell type in our body converts to another cell type. Research carried out at Helmholtz Munich and ...

Evotec and Sartorius partner with start-up Curexsys on iPSC-based exosome approach

Exosomes are a promising novel approach for innovative regenerative therapies, as therapeutics in age-related conditions, but also for diagnostic purposes

10-Dec-2020 - Evotec SE Sartorius announced that they have entered into a partnership with the recently established Curexsys GmbH, a Goettingen, Germany-based technology leader specialising in the emerging field of therapeutic exosomes. Curexsys delivers a proprietary isolation technology for exosomes based on ...

Generation of mouse induced pluripotent stem cells succeeds better without Oct4

11-Nov-2019 - Quality of induced pluripotent stem cells is dramatically enhanced by omitting what was thought to be the most crucial reprogramming factor. Scientists at the Max Planck Institute for Molecular Biomedicine in Münster showed that Oct4, a factor most commonly used for reprogramming, is detrimental ...

Bifacial Stem Cells Produce Wood and Bast

One of the most important growth processes on Earth studied

24-Jan-2019 - So-called bifacial stem cells are responsible for one of the most critical growth processes on Earth – the formation of wood. By alternately developing into wood and bast cells, these stem cells are thus starting points for forming wood as well as generating plant bast fibres. A team of ...

The main switch

3D-DNA folding provides important epigenetic mechanisms in the formation of cardiac muscle cells

23-Nov-2017 - During differentiation of pluripotent stem cells to cardiomyocytes, the three-dimensional folding of the DNA reorganizes itself. This reorganization of the DNA architecture precedes and defines important epigenetic patterns. A team lead by private lecturer Dr. Ralf Gilsbach and Stephan Nothjunge, ...

Repetitive elements shape embryonic chromatin landscape

30-Aug-2017 - Retrotransposons are repetitive elements that form almost half of the mammalian genome. Even though they are so common, they have previously been considered to be fairly insignificant. Together with colleagues from the USA, scientists from the Helmholtz Zentrum München have now shown that ...

Targeting a tumor trigger

16-Mar-2017 - Many cancer patients that receive chemotherapy go into remission at first, but relapse after treatment is discontinued. There is increasing evidence that this is due to the presence of cancer stem cells – cells that reproduce indefinitely and may seed new tumors. A research group from Milan, ...

Axiogenesis and Metrion Biosciences announce stem cell collaboration

Collaboration to develop human iPSC-derived cardiomyocytes and neurons for translational drug discovery

08-Nov-2016 - Axiogenesis AG, a preclinical biotechnology company specialising in the development and production of induced pluripotent stem cell (iPSC)-derived cells and tissues for preclinical applications, and Metrion Biosciences Ltd, the specialist ion channel CRO, have signed a collaboration agreement to ...