Shaping up the Genome for Cell Division

Researchers have uncovered the inner workings of the molecular machinery that shapes chromosomes during cell division

08-Jun-2022 - Our cells perform a marvel of engineering when it comes to packing information into small spaces. Every time a cell divides, it bundles up an amazing 4 metres of DNA into 46 tiny packages, each of which is only several millionths of a metre in length. Researchers from EMBL Heidelberg and ...

Induced pluripotent stem cells reveal causes of disease

Using single-cell analyses, researchers systematically searched for correlations between individual genetic variants in induced pluripotent stem cells

08-Mar-2021 - Induced pluripotent stem cells (iPSC) are suitable for discovering the genes that underly complex and also rare genetic diseases. Scientists from the German Cancer Research Center (DKFZ) and the European Molecular Biology Laboratory (EMBL), together with international partners, have studied ...

Innovative method delivers new insights into the stem cell microenvironment – Bone marrow in 3D

02-Jan-2020 - Researchers from the European Molecular Biology Laboratory (EMBL) and the German Cancer Research Center (DKFZ) in Heidelberg, Germany, have developed new methods to reveal the three-dimensional organisation of bone marrow at a single cell level. Since bone marrow harbours blood stem cells ...

Designer organelles bring new functionalities into cells

EMBL scientists create membraneless organelle to build proteins in living cell

01-Apr-2019 - For the first time, scientists have engineered the complex biological process of translation into a designer organelle in a living mammalian s. Research by the Lemke group at the European Molecular Biology Laboratory (EMBL) – in collaboration with JGU Mainz and IMB Mainz – used this technique to ...

New Ways to Look at Protein-RNA Networks

10-Dec-2018 - For their vital tasks, all RNA molecules in our cells require proteins as binding partners. Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and colleagues from the European Molecular Biology Laboratory (EMBL) have developed the first method with which they ...

Scientists X-ray protein crystals inside cells

Novel approach to unveil the structure of challenging biomolecules

22-Jan-2016 - Scientists from the European Molecular Biology Laboratory EMBL have teamed up with experts from DESY and the U.S. SLAC National Accelerator Laboratory to X-ray protein crystals naturally produced within biological cells. The study at the world's currently most powerful X-ray laser LCLS at SLAC ...

Learning from the linker

New study sheds light on cellular reprogramming

07-Feb-2013 - Mature cells can be reprogrammed to pluripotency and thus regain the ability to divide and differentiate into specialized cell types. Although these so-called induced pluripotent stem cells (iPS cells) represent a milestone in stem cell research, many of the biochemical processes that underlie ...

Scientists open doors to diagnosis of emphysema

EMBL development may provide powerful new test for inflammatory lung diseases

05-Aug-2009 - Chronic inflammatory lung diseases like chronic bronchitis and emphysema are a major global health problem, and the fourth leading cause of death and disability in developed countries, with smoking accounting for 90% of the risk for developing them. Work by scientists at the European Molecular ...

VASTox joins European research consortium to target the development of new treatments for cancer

Research will focus on Cancer Stem Cells as target for new therapies

19-Jan-2007 - VASTox announced that it has become a partner in a new European consortium that will undertake research towards developing new treatments for cancer. The research programme, called Targeting Cancer Stem Cells for Therapy, will be backed by a EUR2 million grant from the European Commission under ...

A new link between stem cells and tumors

06-Sep-2005 - Scientists at the European Molecular Biology Laboratory [EMBL] in Heidelberg and the Institute of Biomedical Research of the Parc Científic de Bar de Barcelona [IRB-PCB] have now added key evidence to claims that some types of cancer originate with defects in stem cells. The study shows that if ...