POC immunoassay for hCG
In the 1990s, advances in the technology of pregnancy tests included the development of antibodies and the use of enzyme labels in place of radioactive labels that were used starting in the 1960s. Now, in the 21st century, human chorionic gonadotropin (hCG) is one of the most common analytes available for Point of Care (POC) testing.
A publication in Clinical Chemistry entitled, “Quantitative, Wide-Range, 5-Minute Point of-Care Immunoassay for Total Human Chorionic Gonadotropin in Whole Blood” by Piia von Lode et al uses Meridian Life Science, Inc. (MLS) # MAF05-043, monoclonal antibody to beta hCG, clone # 057-10043 (OEM Concepts brand) in the development of a POC immunoassay for hCG. This antibody is specific for intact-hCG and its beta subunit. It does not cross react with hCG alpha subunit.
The authors’ achieved their goal of developing a simple and rapid POC assay that relied on noncompetitive assay techniques similar to those in immunoassays used for routine laboratory testing. In addition, their POC assay reacted with hyperglycosylated hCG, nicked hCG, free hCGß, nicked free hCGß and hCGß core fragment.
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Topic world Antibodies
Antibodies are specialized molecules of our immune system that can specifically recognize and neutralize pathogens or foreign substances. Antibody research in biotech and pharma has recognized this natural defense potential and is working intensively to make it therapeutically useful. From monoclonal antibodies used against cancer or autoimmune diseases to antibody-drug conjugates that specifically transport drugs to disease cells - the possibilities are enormous
Topic world Antibodies
Antibodies are specialized molecules of our immune system that can specifically recognize and neutralize pathogens or foreign substances. Antibody research in biotech and pharma has recognized this natural defense potential and is working intensively to make it therapeutically useful. From monoclonal antibodies used against cancer or autoimmune diseases to antibody-drug conjugates that specifically transport drugs to disease cells - the possibilities are enormous