The changing marketplace of antithrombotics: better than cheaper?
Next generation anticoagulant and antiplatelet agents have shown superiority over the current market leaders in clinical studies and are to challenge them before generics
The report provides information on competitor projects in development as novel anticoagulants and antiplatelet agents. Current major targets in anticoagulant R&D are improved drug delivery of low-molecular weigh heparins, improved antithrombin-III agonists, thrombin inhibitors and modulators, indirect and direct F. Xa inhibitors, dual thrombin and F. Xa inhibitors, other factors in the coagulation cascade (F. VIII, F. XI, IX, TF/VII). Antiplatelet R&D focuses on the platelet ADP and thrombin receptor, but new targets such as the von Willebrand Factor / glycoprotein Ib and VI are gaining weight among other new antiplatet approaches. Antithrombotic targets such as PAI-1 and TAFIa are still in the clinical exploratory phase.
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