Viventia Biotech generates novel human anti-cancer antibody, VB1-050, and identifies its novel target

20-Apr-2007

Viventia Biotech Inc. announced that it has generated a novel, fully human anti-cancer antibody, VB1-050, and also identified the novel target for the antibody, a mutant form of the protein Glut-8. The overexpression of this target is predominantly associated with the likelihood of disease metastasis and hence poor patient prognosis. Further research is ongoing to assess the potential clinical exploitation of VB1-050/Glut-8.

VB1-050, an IgG MAb, was generated from pooled lymphocytes of cancer patient samples, using Viventia's Hybridomics(TM) platform. This antibody demonstrates preferential binding to a host of tumor cell lines, including breast, liver, prostate and colon, with limited normal tissue reactivity. Further, internalization of VB1-050 was confirmed by the disappearance of membrane bound VB1-050 and its appearance inside the cell. Viventia Biotech retains full global product rights to VB1-050 and has filed patents on both the antibody and the novel Glut-8 target. The Company is seeking partners capable of complementing Viventia's development expertise with their global sales, marketing and commercial capabilities.

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