Pieris demonstrates potent anti-tumor activity of a VEGF-specific Anticalin in preclinical studies
PRS-050 targets VEGF, a key positive regulator of angiogenesis important in several diseases including cancer and neovascular eye disorders. PRS-050 exhibits a favorable binding and functional in vitro activity profile in direct comparison to all currently approved VEGF antagonists. Strong reduction of VEGF-induced enhanced vascular permeability after systemic administration of PRS-050 was also demonstrated in a second preclinical model. In both in vivo models PRS-050 was at least as efficacious as Avastin® (bevacizumab; Genentech / Roche).
Most read news
Other news from the department research and development
Get the life science industry in your inbox
From now on, don't miss a thing: Our newsletter for biotechnology, pharma and life sciences brings you up to date every Tuesday and Thursday. The latest industry news, product highlights and innovations - compact and easy to understand in your inbox. Researched by us so you don't have to.