A Full Pipeline of Follow-on TNF-Antagonists
The US$ 7.6 bln market of TNF-antagonists attracts numerous follow-on compounds
The range of indications for which at least one of the three branded TNF antagonists obtained approval ranges from rheumatoid arthritis (RA), juvenile RA, psoriatic arthritis, ankylosing spondylitis, Crohn's disease (CD), pediatric CD, ulcerative colitis and psoriasis. Further inflammatory indications such as asthma are under evaluation. The most advancedclinical stage follow-on TNF-antagonist are human or humanized/optimized antibodies in order to reduce the immunogenicity risk seen with chimeric molecules. Small molecules as selective or dual TNF antagonists also have reached clinical evaluation.
The preclinical pipeline of TNF antagonists consists of molecules derived from new technologies or molecules exploring other strategies such as vaccination or oral delivery. Engineered proteins and antibodies make up most of the pipelineattempting to develop and validate the respective technology by using a validated target in an attractive market.
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