An unexpected role for epigenetic enzymes in cancer
In a Yale-led study, Yan and his co-authors focused on a family of enzymes — known as KDM5 — that had been shown in previous studies to be involved in cancer cell growth and spreading.
First author Lauren Blair, an associate research scientist, conducted biochemical studies with Baker’s yeast as the model system, and identified an unexpected role of these enzymes in the process by which genetic messages are interpreted by yeast cells. Further studies showed that the enzymes’ role as regulators of this process is also important for human tumor cells to grow and spread. The finding could lead to a therapy that inhibits the enzyme, and tumor growth, in cancer patients.
Original publication
Other news from the department science
Get the life science industry in your inbox
From now on, don't miss a thing: Our newsletter for biotechnology, pharma and life sciences brings you up to date every Tuesday and Thursday. The latest industry news, product highlights and innovations - compact and easy to understand in your inbox. Researched by us so you don't have to.