TxCell achieves positive results for Col-Treg in a model of autoimmune uveitis

30-Oct-2014 - France

TxCell SA announced that TxCell researchers have achieved positive results for Col-Treg, its second product candidate from its ASTrIA platform, in a model of autoimmune uveitis, a leading cause of blindness with very limited treatment options.

TxCell demonstrated clear efficacy and tolerability of Col-Treg for the treatment of autoimmune uveitis. The results generated in the model include pharmacodynamic and pharmacokinetic data that shows a reduction in the severity of uveitis on clinical and histologic measures. In addition, TxCell has also generated GLP toxicology results that indicate a good safety profile for Col-Treg. TxCell intends to submit these results for publication in a recognized, peer-reviewed journal.

Autoimmune uveitis has been characterised as a disease in which there is a dysfunction of the T regulatory cell compartment of the immune system. Recent scientific studies have demonstrated that the administration or induction of regulatory T (Treg) cells in vivo can be used as therapeutic tools for the control of ocular inflammation, including that seen in autoimmune uveitis. As a result, TxCell is developing Col-Treg as a personalized T cell immunotherapy based on the regulatory properties of autologous collagen-II specific regulatory T lymphocytes. Col-Treg is specifically designed to exert a multi-target, multi-mechanism suppressive and anti-inflammatory action locally in the eye upon recognition of collagen-II, a protein present in the vitreous body of both the eye and retina.

https://www.bionity.com/en/news/150279/txcell-achieves-positive-results-for-col-treg-in-a-model-of-autoimmune-uveitis.html