Synthesis of a selective inhibitor of a fucose binding bacterial lectin from Burkolderia ambifaria
Scientists in Italy report the first example of a synthetic ligand able to selectively bind, in the micromolar range, the pathogen-lectin BambL. BambL is a fucose-specific lectin from Burkholderia ambifaria, a bacterium member of the Burkolderia cepacia complex (BCC), a closely related group of Gram-negative bacteria responsible for cepacia syndrome in immunocompromised patients.
The fucose-based mimetic is therefore a promising candidate for the development of antibacterial agents against infection by B. ambifaria.
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