MorphoSys Reports Promising Pre-clinical Data for MOR202
Combination Studies to be Presented at Annual Meeting of the American Society of Clinical Oncology (ASCO)
In vitro, MOR202 mediates the killing of multiple myeloma cells by antibody-dependent cellular cytotoxicity (ADCC). In combination with the drug bortezomib (Velcade®), MOR202 displayed an enhanced direct cytotoxic effect on multiple myeloma cells. The drug lenalidomide (Revlimid®) synergistically enhanced MOR202 activity on multiple myeloma cells by several mechanisms, including direct cytotoxicity, activation of effector cells and increased CD38 expression levels on the tumor cell surface.
In an in vivo mouse model of multiple myeloma, MOR202 reduces tumor load as well as tumor-mediated bone destruction. In this model, MOR202 in combination with either bortezomib or lenalidomide completely abolished bone destruction in a synergistic manner. These findings support further investigation of MOR202 combination regimens in clinical trials.
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Topic world Antibodies
Antibodies are specialized molecules of our immune system that can specifically recognize and neutralize pathogens or foreign substances. Antibody research in biotech and pharma has recognized this natural defense potential and is working intensively to make it therapeutically useful. From monoclonal antibodies used against cancer or autoimmune diseases to antibody-drug conjugates that specifically transport drugs to disease cells - the possibilities are enormous
Topic world Antibodies
Antibodies are specialized molecules of our immune system that can specifically recognize and neutralize pathogens or foreign substances. Antibody research in biotech and pharma has recognized this natural defense potential and is working intensively to make it therapeutically useful. From monoclonal antibodies used against cancer or autoimmune diseases to antibody-drug conjugates that specifically transport drugs to disease cells - the possibilities are enormous