Molecular Partners reports positive results from its first clinical studies
MP0112 is safe and effective in two separate phase I/IIa trials
Molecular Partners AG announced that it has completed two phase I/IIa clinical trials with MP0112, its lead molecule targeting VEGF-A. The DARPin molecule was shown to be safe and well tolerated in two separate Phase I/IIa trials in wet age-related macular degeneration (wet AMD) and Diabetic Macular Edema (DME).
Patients were recruited globally in the US and several European countries. The detailed results will be presented at the annual meeting of the Association for Research in Vision and Ophthalmology (ARVO) in Fort Lauderdale, FL (May 1st – 5th).
Two parallel trials, together including 50 wet AMD or DME patients, have shown that MP0112 is safe and well tolerated when given as a single intravitreal injection. Overall, the studies have indicated that MP0112 has high efficacy and long duration of action. The therapeutic effect was demonstrated to be dose dependent and to last for most of the patients of the higher dose cohorts for 16 weeks and beyond after a single injection of MP0112.
MP0112 was engineered to have a long ocular half-life and fast systemic clearance. Thus, it has the potential to become the best-in-class treatment of neovascular diseases of the eye, reducing the number of intravitreal injections needed as compared to current approved standard of care and possibly omitting the need for monthly loading doses.
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