New genetic marker makes fruit fly a better model for the study of neuronal development and human brain disorders

16-Nov-2010 - Belgium

VIB researchers attached to the K.U.Leuven have improved the fruit fly as a model for studying the connections between brain cells. The researchers developed a specific marker for a part of the fly's nerve cell which had previously been difficult to distinguish. Their discovery will not only contribute to gaining a better insight into brain development but also makes the fruit fly into a better model system for studying brain development and brain disorders.

The fruit fly, Drosophila melanogaster, is an important, low-cost model organism with 60% genetic similarity with humans. The fruit fly plays a significant role in clarifying various neurological processes such as the way our memory works and our sense of smell and in studying particular neurodegenerative diseases. The team headed by Bassem Hassan uses the fruit fly as a model to study brain development.

Though Drosophila has long been used to study the connections between nerve cells, one specific marker was still missing. To understand the whole circuit between nerve cells, markers are needed for the different compartments of nerve cells (presynaptic or output cells and postsynaptic or input cells).

Under the direction of Bassem Hassan and in collaboration with Wim Annaert, Laura Nicolaï, Ariane Ramaekers and their colleagues have identified the missing marker, DenMark (Dendritic Marker), a hybrid of a mouse protein and a fluorescent protein. The high specificity of such a marker for the input compartment of the nerve cells in Drosophila gives rise to hope that it can also be used in other model organisms.

Original publication: Nicolaï et al.; "Genetically encoded dendritic marker sheds light on neuronal connectivity in Drosophila"; PNAS 2010.

https://www.bionity.com/en/news/125976/new-genetic-marker-makes-fruit-fly-a-better-model-for-the-study-of-neuronal-development-and-human-brain-disorders.html