baseclick working towards mRNA therapeutic development utilizing the Nobel Prize awarded “Click Chemistry” bioconjugation technology

16-Nov-2022 - Germany

baseclick has adapted the “Click Chemistry” bioconjugation method for many applications in nucleic acid modification –including the modification of oligomeric nucleic acids such as DNA, RNA oligos as well as mRNA. In 2022, Prof. Dr. Carolyn R. Bertozzi, Prof. Dr. Morten Meldal and Prof. Dr. K. Barry Sharpless, mentor of baseclick’s click chemistry modification technology, were awarded the chemistry Nobel Prize from the Royal Swedish Academy of Sciences, “for the development of click chemistry and biorthogonal chemistry”.

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baseclick has started its own COVID-19 mRNA program utilizing its mRNA modification technology to target sugar modified mRNA specifically to immune cells to raise an immune response against the N-protein of SARS-CoV2, obtaining a positive evaluationfrom the Paul Ehrlich Institute.

Dr. Frischmuth, CEO and inventor of the Click Chemistry mRNA modification technology, expressed his satisfaction for the progress made and his hope “to accelerate the development of mRNA as a new therapeutics class.”

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