Cornell team investigates how to starve tumors
The research team - including Claudia Fischbach-Teschl, assistant professor of biomedical engineering; Abe Stroock and Jeff Varner, assistant professors of chemical and biomolecular engineering; and Vivek Mittal, associate professor of cardiothoracic surgery at Weill Cornell Medical College - will receive $633,000 over two years. The funding will support three graduate students and a postdoctoral researcher to work on the project.
Among other things, the researchers hope that developing a microfluidic 3-D tumor model will allow them to examine how such essential soluble elements as dissolved oxygen are transported in blood to tumors. The researchers will also flood the system with bone marrow-derived stem cells that play a role in tumor vascularization.
"We will look at how and where they incorporate and be able to study these cells qualitatively and quantitatively," said Fischbach-Teschl.
The researchers will also use mathematical modeling to study underlying molecular signaling pathways involved in tumor angiogenesis.
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