SAIC-Frederick and Roche Enter into a Research Collaboration on Technology Advancements for Cancer Gene Sequencing

30-Sep-2009 - USA

National Cancer Institute contractor SAIC-Frederick, Inc., a wholly owned subsidiary of Science Applications International Corporation, and Roche Applied Science, a division of Roche Diagnostics Corporation, have signed a collaboration agreement to assess Roche’s advanced technologies to sequence the genomes of cancer research samples. These technologies include targeted enrichment with NimbleGen Sequence Capture and ultra-deep sequencing using the Genome Sequencer FLX System from 454 Life Sciences, a Roche Company.

Under the recently-signed agreement, SAIC-Frederick’s Core Genotyping Facility will capture specific regions of the genome of a cancer research sample. The captured DNA will then be sequenced on the ultra high-throughput Genome Sequencer FLX System. Implementation of this technology could accelerate the identification of genetic variants, such as DNA polymorphisms, that contribute to cancer outcomes.

The agreement was formed under the National Cancer Institute’s Advanced Technology Partnerships Initiative (ATPI). SAIC-Frederick aims to further NCI’s mission by rapidly translating the results of basic research into new preventive measures, diagnostic tests, and effective, patient-specific treatments for cancer patients. As a prime contractor at the National Cancer Institute at Frederick, SAIC-Frederick is facilitating ATPI partnerships for the government.

“Our ability to understand the impact of particular regions of the human genome with cancer phenotypes is rapidly advancing with the advent of next-generation sequencing technologies,” said Joseph Boland, Dedicated Scientific Operations Manager of the Core Genotyping Facility at SAIC-Frederick. “Our intent is to implement Roche NimbleGen’s solution-based sequence capture technology, SeqCap EZ, to rapidly advance our next-generation sequencing projects and in turn, increase our knowledge of cancer genetics.”

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