Vandria SA

Vandria is at the vanguard of mitochondrial therapeutics. It is developing first-in-class mitophagy inducers that rejuvenate cells to treat age-related and chronic diseases. Its lead program, VNA-318 is a brain-penetrant, patent-protected, mitophagy inducer which has been shown to acutely improve memory and learning and to have strong disease-modifying effects in models of neurodegenerative disease such as Alzheimer’s and Parkinson’s Disease. VNA-318 is expected to enter the clinic in Q2 2024. The company is also developing mitophagy-inducing small molecules to address muscle, lung, and liver diseases. A separate program targets ferroptosis, a form of cell death implicated in neurodegenerative diseases and ischemia reperfusion injury.

Based in Lausanne Switzerland, Vandria was spun out of Amazentis SA in 2021 by its founders Patrick Aebischer, Chris Rinsch, and Johan Auwerx. The company has raised $20.6M (CHF18M) in venture finance. Its lead investor is ND Capital.