Adapting the Power of Density Gradient Separations for Gene Therapy Analytics
DGE-AUC (Density Gradient Equilibrium AUC) highly simplified analytical method
Density gradient ultracentrifugation (DGUC) has long been considered a staple technology providing high-resolution purification of numerous materials in gene therapy, including AAV, adenovirus, and plasmids, from bench to manufacturing scales. With DGE-AUC you can monitor and quantify this density gradient process to get the simple, intuitive nature of DGUC (Gold standard for purification) in an analytical instrument (Optima AUC) with a high resolution, high senssitive, and serotype independent method.
DGE-AUC advantages:
- More Data (DGE AUC is orthogonal to well established SV AUC methods)
- Less Sample (more than 30X greater sensitivity is achievable)
- Higher Throughput (at least 3x samples; e.g., 6 sector CPs)
- Higher Resolution (not time resolved; no wavelength/resolution trade off; scan averaging)
- More Straightforward (rapid, intuitive data interpretation with Excel)
- More Sample Types (serotype agnostic; not size limited; e.g., AAV, adeno, plasmids)
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Adapting the Power of Density Gradient Separations for Gene Therapy Analytics
DGE-AUC (Density Gradient Equilibrium AUC) highly simplified analytical method
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Topic world Gene therapy
Genetic diseases once considered untreatable are now at the center of innovative therapeutic approaches. Research and development of gene therapies in biotech and pharma aim to directly correct or replace defective or missing genes to combat disease at the molecular level. This revolutionary approach promises not only to treat symptoms, but to eliminate the cause of the disease itself.
Topic world Gene therapy
Genetic diseases once considered untreatable are now at the center of innovative therapeutic approaches. Research and development of gene therapies in biotech and pharma aim to directly correct or replace defective or missing genes to combat disease at the molecular level. This revolutionary approach promises not only to treat symptoms, but to eliminate the cause of the disease itself.
Topic world Centrifugation
Centrifugation is an indispensable process in the life sciences. By using centrifugal forces, it enables the separation of cells, proteins and other biomolecules according to size and density. Whether in the purification of therapeutic proteins, the isolation of DNA/RNA or the separation of cell cultures - centrifugation plays a central role in biological and pharmaceutical research and production.
Topic world Centrifugation
Centrifugation is an indispensable process in the life sciences. By using centrifugal forces, it enables the separation of cells, proteins and other biomolecules according to size and density. Whether in the purification of therapeutic proteins, the isolation of DNA/RNA or the separation of cell cultures - centrifugation plays a central role in biological and pharmaceutical research and production.
