What triggers the programmed cell death mechanism?

Development and combination of various microscopic and spectroscopic techniques

13-Sep-2024 - How can molecular structures be analysed when the resolution of the techniques available is not sufficient? Researchers from the fields of physics, chemistry and medicine at Heinrich Heine University Düsseldorf (HHU) have combined and further developed various microscopic and spectroscopic ...

Frequency-domain STED microscopy for selective background noise suppression

Novel method suppresses background noise in STED microscopy selectively and effectively, with potential for integration into other dual-beam point-scanning techniques

08-Jul-2022 - Nanoscopy describes the ability to see beyond the generally accepted optical limit of 200–300 nm. Stimulated emission depletion (STED) microscopy, developed by Stefan W. Hell and Jan Wichmann in 1994, and experimentally demonstrated by Hell and Thomas Klar in 1999, is a superresolution technique ...

New microscopy method resolves fluorescent molecules with resolution at the nanometer scale

22-Mar-2021 - Scientists working with Stefan Hell at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen and the Heidelberg-based MPI for Medical Research have developed another light microscopy method, called MINSTED, which resolves fluorescently labeled details with molecular sharpness. ...

Tracking the HI virus

Researchers makes visible, how AIDS pathogens multiply in the body

07-Oct-2019 - An international team of researchers led by Dr Cyril Favard and Dr Delphine Muriaux from the Montpellier Infectious Disease Research Institute in collaboration with Prof. Dr Christian Eggeling from the Friedrich Schiller University Jena, the Leibniz Institute of Photonic Technology (Leibniz ...

Researchers combine light and X-ray microscopy for comprehensive insights

11-Sep-2018 - Researchers at the University of Goettingen have used a novel microscopy method. In doing so they were able to show both the illuminated and the "dark side" of the cell. The team led by Prof. Dr. Tim Salditt and Prof. Dr. Sarah Köster from the Institute of X-Ray Physics "attached" small ...

Suitable Protein Tags for Nanoscopy

02-Feb-2016 - Modern optical technologies such as super-resolution nanoscopy enable to exactly image small structures and molecular processes, therefore, providing a fascinating view into living cells. To visualize such processes in the nanometer range, cellular structures of interest have to be efficiently ...

Imaging techniques set new standard for super-resolution in live cells

31-Aug-2015 - Scientists can now watch dynamic biological processes with unprecedented clarity in living cells using new imaging techniques developed by researchers at the Howard Hughes Medical Institute's Janelia Research Campus. The new methods dramatically improve on the spatial resolution provided by ...

Leica Microsystems’ STED Super-Resolution Microscope Again Awarded for its Innovative Technology

The Scientist Top 10 Innovations Award for Leica TCS SP8 STED 3X

03-Dec-2014 - The Scientist magazine has chosen the Leica TCS SP8 STED 3X as one of the Top 10 Innovations 2014 that will change the way life scientists work. An independent jury of experts from science and industry selected the latest generation of Leica Microsystems’ super-resolution microscopes. This is the ...

The Nobel Prize in Chemistry 2014: Surpassing the limitations of the light microscope

Eric Betzig, Stefan W. Hell and William E. Moerner are awarded the Nobel Prize in Chemistry

08-Oct-2014 - For a long time optical microscopy was held back by a presumed limitation: that it would never obtain a better resolution than half the wavelength of light. Helped by fluorescent molecules the Nobel Laureates in Chemistry 2014 ingeniously circumvented this limitation. Their ground-breaking work ...

Sharp images from the living mouse brain

Max Planck scientists in Goettingen have for the first time made finest details of nerve cells in the brain of a living mouse visible

08-Feb-2012 - To explore the most intricate structures of the brain in order to decipher how it functions – Stefan Hell's team of researchers at the Max Planck Institute for Biophysical Chemistry in Göttingen has made a significant step closer to this goal. Using the STED microscopy developed by Hell, the ...