TOYOPEARL Super A Resin

TOYOPEARL Super A resin provides a cutting-edge experience in protein A media, blending top-tier critical performance attributes with exceptional operational flexibility.

An enhanced, Animal Origin Free, recombinant Protein A ligand is bound to the polymethacrylate base bead via multipoint attachment resulting in excellent base stability for up to 100 CIP cycles with 0.5 mol/L NaOH and up to 70 CIP cycles with 1 mol/L NaOH  while  maintaining 90 % of its initial DBC.

TOYOPEARL Super A resin is available in ~45 µm particle size (F-grade) and exhibits dynamic binding capacities of greater than 70 g/L at 5 minutes residence times and greater than 60 g/L at 3 minutes residence time. Improved mass transfer characteristics allow it to maintain a larger percent of its capacity at lower residence times relative to comparable agarose based resins. It is therefore ideally suited for continuous operation using multiple short columns. This resin is also available in pre-packed SkillPak columns to simplify your process development and scale up.

Highlights

• State-of-the-art operational flexibility: Supports high titers with high dynamic binding capacity (DBC), enhanced alkaline stability for rigorous CIP, and excellent pressure flow behavior to increase process efficiency.
• Superior critical process performance: Features mild elution conditions, concentrated elution vol