Celsius® FT100

Celsius^® FT100 is a controlled-rate freeze & thaw system designed to minimize the adverse effects of the cryoconcentration in your biopharmaceutical products. This modular equipment provides flexibility for processing up to 100L of solution with single-use Celsius^® Paks.

The Celsius® FT100 was developed for freezing and thawing 1L, 2L, 8.3L and 16.6L Celsius® Paks.

The system is equipped with:

Three Cryo Chambers

The Heat Transfer Fluid (HTF) circulates inside heat transfer plates that are mounted on each chamber. Once a freeze or thaw cycle is initiated, the Celsius^® FT100 ensures excellent contact between the plates and the Celsius^® Pak surface to optimize the heat transfer. The Celsius^® FT100 is mounted on rockers that allow the chamber to rock back and forward during thawing processes. This rocking movement optimizes the mixing of the liquid and solid phases of the product, improving thawing time and ensuring product homogeneity.

Conceived to minimize operator efforts, each chamber has a docking locator to align the Transfer Cart or the Celsius^® SSM in order to simplify the transfer of the Celsius^® Paks to and from each chamber.

Temperature Control Unit

The Temperature Control Unit (TCU) allows robust and reproducible freeze and thaw cycles. The TCU controls the freeze and thaw processes by supervising the temperature and flow rate of the heat transfer fluid according to predefined recipes.

Control Cabinet

The entire automatic freeze, thaw and hold operations are processed through the control cabinet. It is linked to the TCU and the freeze and thaw chambers via Profinet. The critical parameters of all processes are commanded, monitored and stored in an automatic manner with minimal operator intervention. The Human Machine Interface (HMI) is a touch screen panel PC connected to a Siemens PLC. All relevant process values are recorded with the WINCC software.