Markers in iPSC quality control – a new approach to enhance standardization

“Machine learning is an attractive tool to streamline processes”

12-Nov-2024 - Human induced pluripotent stem cells (iPSCs) have a great potential for scientific and medical applications. They are used in research laboratories to model human diseases, helping to uncover underlying mechanisms and developing new therapies. Additionally, they are being tested in clinical ...

With AI and lasers to fully automated cell selection

Continuous movement versus stop-and-go process

14-Mar-2024 - Tests on living cell cultures are becoming increasingly important for personalized medicine, drug development and clinical research. The Aachen-based Fraunhofer Institutes for Laser Technology ILT and for Production Technology IPT have developed an AI-assisted high-throughput process that now ...

A mini-heart in a Petri dish: organoid emulates the development of the human heart

New cell type discovered

06-Apr-2023 - A team at the Technical University of Munich (TUM) has induced stem cells to emulate the development of the human heart. The result is a sort of “mini-heart” known as an organoid. It will permit the study of the earliest development phase of our heart and facilitate research on diseases. The ...

Mapping human brain development

With the help of brain organoids, ETH researchers are investigating gene networks that control the development of different brain regions

12-Oct-2022 - Researchers at ETH Zurich are growing human brain-​like tissue from stem cells and are then mapping the cell types that occur in different brain regions and the genes that regulate their development. The human brain is probably the most complex organ in the entire living world and has long been ...

Stem cell secrets allow researchers to revamp reprogramming

Researchers have identified factors required to generate naïve stem cells by reprogramming

30-Mar-2022 - Researchers from the Babraham Institute’s Epigenetics research programme have been able to learn more about naïve stem cell reprogramming following a genome wide functional screen. Their research, published in Science Advances, describes the critical regulators of reprogramming and offers ...

Embryonic development in cell culture

Research group can for the first time reproduce early human heart development in a culture dish using human pluripotent stem cells

11-Feb-2021 - To study early stages in embryonic development in the cell culture dish, scientists use so-called human pluripotent stem cells (hPSC). These are cells with have remarkablespecial properties that can be multipliedas they can indefinitely multiply and are capable of forming any functional cell type ...

Researchers create human airway stem cells from patients' cells

Advancing regenerative research for lung diseases, results could lead to new treatments for airways and lungs damaged by COVID-19, influenza, asthma and cystic fibrosis

27-Oct-2020 - For the first time, researchers have successfully created airway basal stem cells in vitro from induced pluripotent stem cells by reprogramming blood cells taken from patients. Given that airway basal cells are defined as stem cells of the airways because they can regenerate the airway epithelium ...

Neandertal genes in the petri dish

Researchers are studying the Neandertal DNA found in modern humans using stem cells and organoids

22-Jun-2020 - Protocols that allow the transformation of human induced pluripotent stem cell (iPSC) lines into organoids have changed the way scientists can study developmental processes and enable them to decipher the interplay between genes and tissue formation, particularly for organs where primary tissue ...

Beta cells from stem cells: Potential for cell replacement therapy

Quality control with CD177 can help save lots of time, efforts and money

29-Apr-2020 - The loss of insulin-secreting beta cells by autoimmune destruction leads to type 1 diabetes. Clinical islet cell transplantation has the potential to cure diabetes, but donor pancreases are rare. In a new study, a group of researchers developed an improved pluripotent stem cell differentiation ...

Unlimited potential: New ways to generate totipotent-like cells

13-Jan-2020 - Totipotency is set to become a key tool for research and future medical applications. Finding efficient ways to generate totipotent-like cells is therefore crucial. In a new study, a group of researchers at Helmholtz Zentrum München found that totipotent-like cells can be induced by manipulating ...