Reprogrammed fat cells support tumor growth

05-Jan-2024 - Mutations of the tumor suppressor p53 not only have a growth-promoting effect on the cancer cells themselves, but also influence the cells in the tumor's microenvironment. Scientists at the German Cancer Research Center (DKFZ) and the Weizmann Institute in Israel have now shown that p53-mutated ...

Curcumin activates tumor suppressive signaling pathway

Researchers have identified a signaling pathway via which curcumin can suppress the metastasis of colorectal cancer cells

31-May-2023 - Colorectal cancer is one of the most common types of cancer worldwide. In over half of all cases, an important protective mechanism in cells is inactivated by mutations – the tumor suppressor gene p53. The product of this gene, a transcription factor, induces a microRNA molecule called miR-34, ...

Interplay of genes

Little-known transcription factor RFX7 has central role in growth and cancer

22-Jul-2022 - Cancer research focuses on proteins that often appear altered in tumors and may play an important role in cancer. The RFX7 protein, a largely unknown transcription factor, has recently been linked to lymphoma. Researchers at the Leibniz Institute for Aging Research - Fritz Lipmann Institute (FLI) ...

Certain proteins determine the life or death of the cell

Scientists at Med Uni Graz research aging cells

05-Aug-2021 - Researchers at the Medical University of Graz, together with international colleagues, have investigated which molecular processes in the body are responsible for the regulation of the FOXO4 tumour suppressor and thus determine whether cells proliferate or die, which plays a central role in ...

How molecular escorts help prevent cancer

Chaperones keep the tumor suppressor protein p53 in check

23-May-2019 - The anti tumor protein p53 can decide on the life or death of a cell: If it detects damage in the cell's genome, the protein pushes the cell to suicide. New research conducted at Technical University of Munich (TUM) shows that this inborn cancer prevention only works when special proteins, known ...

Newly discovered protein prevents undisturbed proliferation of cancer cells

23-Mar-2018 - An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can ...

A sensor for the most important human cancer gene

Molecular “detector” recognizes most frequent cancer-mutation in cells and initiates to kill them

15-Nov-2017 - If it burns in a house smoke detectors alert us hence protecting life. A molecular smoke alert has now been developed by Dresden researchers for the TP53 gene, the most important human cancer gene. The alert goes on if the TP53 gene is mutated in cells. The molecular smoke detector works like a ...

New research offers hope to neuro-tumor patients

11-Jul-2017 - New research published in the journal Oncogene could offer hope to the thousands of, mainly young, people affected by the hereditary condition Neurofibromatosis 2 (NF2). This condition is characterised by the development of multiple tumours of the nervous system such as schwannomas, meningiomas ...

New insights into mechanisms of breast cancer development and resistance to therapy

11-Jan-2017 - Why does breast cancer develop and how come certain patients are resistant to established therapies? Researchers from the University of Basel have gained new insights into the molecular processes in breast tissue. They identified the tumor suppressor LATS as a key player in the development and ...

Potentially druggable mutant p53 proteins that promote cancer growth identified

09-Dec-2016 - Discovered in the 1970s, tumor suppressors are among the most important proteins in the body. A master regulator of growth -- "the guardian of the genome" -- the p53 protein monitors cell growth for errors. We rely on suppressors like p53 to defeat cancer before it takes root. Indeed, cancer ...