Signatures of of heart attack - Multi-omics factor analysis provides new insights

Analysed for the first time: How does the immune system react to a heart attack?

23-May-2024 - Improving the outcome of patients after a heart attack is one of the major challenges of cardiology. This includes a comprehensive understanding of the pathophysiology and early detection of those patients who have a high risk of an unfavorable outcome. Researchers at LMU University Hospital, ...

New mechanism for regulating cell division in the bacterial pathogen Klebsiella uncovered

Small ribonucleic acid with a big impact

23-Feb-2024 - Klebsiella pneumoniae is one of the most common and most dangerous bacterial pathogens impacting humans, causing infections of the gastrointestinal tract, pneumonia, wound infections and even blood poisoning. With the aim of discovering therapeutically exploitable weaknesses in Klebsiella, a ...

What can bulls tell us about men?

Towards a better understanding: Which genes and mechanisms control male fertility?

19-Feb-2024 - Researchers have found genes in the reproductive organs of bulls that influence fertility. The findings can be transferred to humans, as these genes are also present in men. Infertility is a widespread problem: worldwide, one in eight couples fail to fulfil their desire to have children within a ...

Large-scale mapping of pig genes could pave the way for new human medicines

Researchers have carried out complex genetic analyses of hundreds of pigs and humans to identify differences and similarities

12-Jan-2024 - It may sound strange, but we can actually learn more about ourselves by studying pigs. Pigs and humans are pretty similar. Our organs, our skin and the way many diseases develop are largely the same. Pigs have therefore long been used to develop and test new medicines, even though pigs are ...

Gene activity in a test tube

An accurate picture of gene activity can provide the key to the development of new, targeted therapies

18-Oct-2022 - When searching for the causes of illnesses and developing new treatments, it is absolutely vital to have a precise understanding of the genetic fundamentals. Würzburg researchers have devised a new technique for this purpose. Pathological processes are usually characterised by altered gene ...

When macrophage digestion goes wrong

If a secretion in the lungs’ alveoli is not cleared regularly, breathing difficulties can develop.

20-Sep-2022 - In a study published in Science Immunology, a team led by Alexander Mildner and Achim Leutz has now explained the pivotal role of the transcription factor C/EBPb in this process. The exchange of gases between the air we breathe and our blood takes place via alveoli – tiny air sacs in our lungs. ...

Monitoring gene activities in living cells

Cell Biopsy instead of cell lysis

19-Aug-2022 - Researchers from ETH Zurich and EPFL are expanding the emerging field of single-​cell analysis with a ground-​breaking method: Live-​seq makes it possible to measure the activity of thousands of genes in a single cell without having to isolate and destroy it. Modern biology is increasingly ...

Double agents: How stomach stem cells change allegiance upon injury

Adult stem cells are more complex than we might have thought

10-May-2022 - A stomach adult stem cell population can fulfill two distinct functions: either help with digestion under normal conditions or take the lead on injury response. Scientists at IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, demonstrate that these functions are two ...

New tool integrates microbiome and host genetic sequencing analysis

A new software tool makes it easier to study relationships between a host, its microbiome and pathogens like HIV or SARS-CoV-2

10-May-2022 - Researchers at Texas Biomedical Research Institute and Tulane University have developed a new software tool that makes it easier, faster and more cost effective to analyze genetic information about a host and its microbiome at the same time. The software, called “meta-transcriptome detector” ...

Strong antiviral immunity in the upper airways protects children from severe COVID-19

19-Aug-2021 - Children can also be infected with the novel coronavirus SARS-CoV-2, but have a substantially lower risk for developing severe COVID-19 disease compared to adults. A team of scientists from the Berlin Institute of Health at Charité (BIH), Charité – Universitätsmedizin Berlin, University of ...