Gene therapy against hemophilia

Hannover Medical School (MHH) is one of the first institutions in Germany to be authorized to carry out a new innovative treatment for haemophilia A and B

07-Oct-2024 - Cell and gene therapies are on the rise. This is a new glimmer of hope for people with previously untreatable or barely treatable diseases. Another new therapeutic method has now been added to the list: gene therapy for hemophilia, also known as bleeding disorder. The Hemophilia Center at ...

New disease discovered: How the immune system destroys the cerebellum

Study identifies new autoantibodies in cerebrospinal fluid as a possible biomarker for rapidly progressing cerebellitis

03-Jun-2024 - Cerebellar ataxia is a neurological disorder of the cerebellum. This important area at the back of the brain acts as a conductor, so to speak, coordinating our movements and keeping us in balance. This ability is impaired in cerebellar ataxia. Affected people can have difficulties walking, ...

The virus hackers: RNAi therapy for viral respiratory diseases

Inhalation as a silver bullet

05-Feb-2024 - A research team from the Fraunhofer Institute for Toxicology and Experimental Medicine ITEM and the Hannover Medical School (MHH) have made significant progress in developing a new antiviral therapy. The drug, which is inhaled, uses RNAi to target and deactivate parainfluenza viruses before they ...

Mutating Hepatitis Viruses Make Drug Treatment More Difficult

Study paves the way for the next generation of active substances

31-Jan-2024 - A combination therapy with multiple drugs is more effective than just one active compound. To begin with, at least. Hepatitis E affects over 20 million people worldwide. It clears up without any consequences in most cases, but it can pose a risk to pregnant women and immunocompromised patients. ...

Keeping organ rejection in check with killer cells

Therapeutic potential not only for transplant medicine

06-Dec-2023 - A donated organ always remains foreign to the body and is fought against by the immune system. In order to prevent rejection, the entire immune defence must be suppressed for a lifetime. An MHH research team is now using genetically modified killer cells against precisely those immune cells that ...

New gene taxis to combat liver disease

Research team finds two promising AAV capsid variants for gene therapy in the liver

31-Oct-2022 - There are numerous severe, hardly treatable monogenetic diseases that are caused by a defect in a single gene - also in the liver. These include the blood coagulation disorders haemophilia A or B or the metabolic disease phenylketonuria. Gene therapies could help here, in which intact genes are ...

New test to make gene therapy safer

SAGA detects tumour potential of viral vectors for blood stem cells

09-Jul-2021 - When the causes of serious diseases are based on a defective gene, medicine relies on gene therapy. In this strategy, defect-free genes are introduced into the body with the help of certain viruses. In this way, individual forms of congenital blindness, hereditary muscular atrophy or certain ...

MHH Researchers scrutinize EC Regulation

500.000 Euros of funding for an assessment of regulatory impact on Advanced Therapies

01-Dec-2010 - A team of researchers from the United Kingdom, Sweden, Austria and Germany, with Professor Dr Martin Hildebrandt, Integrated Research and Treatment Center Transplantation (IFB-Tx), Hannover Medical School MHH) as coordinator, are setting up a platform for Academic GMP Institutions. GMP - Good ...

Ascenion Mediates Licence Agreement between medac and MHH for New Diagnostic Test in Acute Lymphoblastic Leukaemia (ALL)

30-Mar-2009 - Hanover Medical School (MHH) and medac GmbH have closed a licence agreement providing the company with exclusive worldwide rights to a diagnostic test that can help guide Acute Lymphoblastic Leukaemia (ALL) treatment. The deal was initiated and negotiated by Ascenion GmbH, the MHH's exclusive ...