CRISPR-Cas9 corrects sickle cell mutation

Collaborative effort to reduce off-target CRISPR-Cas9 genome editing

08-Aug-2018 - Genome editing using the CRISPR-Cas9 system has tremendous promise for therapeutic correction of genetic errors in human cells. Prior to adoption as a medical therapeutic, safety concerns relating to off-target effects must be minimized to mitigate risks that may arise from the unintended action ...

Scientists map epigenetic changes during blood cell differentiation

Potential application for stem cell therapies

17-Aug-2010 - Having charted the occurrence of a common chemical change that takes place while stem cells decide their fates and progress from precursor to progeny, a Johns Hopkins-led team of scientists has produced the first-ever epigenetic landscape map for tissue differentiation. The details of this ...

Virus-free technique enables Stanford scientists to easily make stem cells pluripotent

09-Feb-2010 - Tiny circles of DNA are the key to a new and easier way to transform stem cells from human fat into induced pluripotent stem cells for use in regenerative medicine, say scientists at the Stanford University School of Medicine. Unlike other commonly used techniques, the method, which is based on ...

Stanford researchers explore link between human birth defect syndrome, cancer metastasis

05-Feb-2010 - Some cells are natural rule-breakers. Neural crest cells for example, not only migrate throughout the body during development (most cells are more selective in their wandering), they are also more developmentally flexible than their predecessors (a no-no for nearly all cell types). Now ...

'Liposuction leftovers' easily converted to IPS cells, Stanford study shows

09-Sep-2009 - Globs of human fat removed during liposuction conceal versatile cells that are more quickly and easily coaxed to become induced pluripotent stem cells, or iPS cells, than are the skin cells most often used by researchers, according to a new study from Stanford's School of Medicine. "We've ...

2 lines account for most human embryonic stem cell research, Stanford scholar finds

11-Aug-2009 - For the past eight years, scientists who wanted to use federal funds for research on human embryonic stem cells had to restrict their studies to 21 cell lines approved by the National Institutes of Health. But an analysis by a researcher at the Stanford University School of Medicine suggests that ...

Implants that Respond to Your Body

Dynamic, 3D Pattern Formation within Protein-based Gels

04-Aug-2009 - Modern regenerative medicine is on the lookout for implantable materials that can change as the surrounding tissue does, and two Stanford University researchers have made some new gel materials that do just that. Karin Straley and Professor Sarah Heilshorn have developed a method for preparing ...

From stem cells to new organs: Stanford and NYU scientists cross threshold in regenerative medicine

Research in the FASEB Journal clears major hurdles for bioengineered replacement organs

02-Mar-2009 - By now, most people have read stories about how to "grow your own organs" using stem cells is just a breakthrough away. Despite the hype, this breakthrough has been elusive. A new report published in The FASEB Journal brings bioengineered organs a step closer, as scientists from Stanford and New ...

Stanford Scientists Pinpoint Key Proteins in Blood Stem Cell Replication

10-Oct-2008 - A family of cancer-fighting molecules helps blood stem cells in mice decide when and how to divide, say researchers at the Stanford University School of Medicine. Blocking the molecules’ function spurs the normally resting cells to begin proliferating strangely - making too much of one kind of ...

Ethical Guidelines Suggested for Research that Would Put Human Stem Cells in Primates

Stanford Law Professor Says Recommendations Could 'Minimize Ethical Risks'

15-Jul-2005 - Before conducting research that involves putting human stem cells into the brains of nonhuman primates such as monkeys or apes, scientists and oversight committees should consider a series of ethical criteria, according to a policy paper released in the July 15 issue of Science. The policy ...