Scientists sharpen their molecular scissors and expand the gene editing toolbox

26-Feb-2019 - Wake Forest Institute for Regenerative Medicine (WFIRM) scientists have figured out a better way to deliver a DNA editing tool to shorten the presence of the editor proteins in the cells in what they describe as a "hit and run" approach. CRISPR (clustered regularly interspaced short palindromic ...

Advancing stem cell therapy with biodegradable scaffold

New technology is aimed at central nervous system diseases and injuries

06-Nov-2018 - Rutgers scientists have created a tiny, biodegradable scaffold to transplant stem cells and deliver drugs, which may help treat Alzheimer's and Parkinson's diseases, aging brain degeneration, spinal cord injuries and traumatic brain injuries. Stem cell transplantation, which shows promise as a ...

Restoring tissue with inspiration from plants and animals

20-Mar-2018 - Researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) and the Wyss Institute for Biologically Inspired Engineering have developed new wound dressings that dramatically accelerate healing and improve tissue regeneration. The two different types of nanofiber ...

Super-silenced DNA hints at new ways to reprogram cells

09-Jan-2018 - Newly described stretches of super-silenced DNA reveal a fresh approach to reprogram cell identity to use in regenerative medicine studies and one day in the clinic, according to a study by investigators from the Perelman School of Medicine at the University of Pennsylvania. "In the past, most ...

How does a cell maintain its identity during replication?

18-Sep-2017 - Prior to cell division, chromosomes are seemingly a jumbled mess. During cell division, parent cell chromosomes and their duplicates sort themselves out by condensing, becoming thousands of times more compact than at any other time. Researchers have long assumed that genes become "silent" during ...

3-D printed ovaries produce healthy offspring

18-May-2017 - Used 3-D printing to create bioprosthetic mouse ovary to restore fertility, boost hormone production Targeted to women who survived childhood cancer, have had treatments that affect hormones and fertility "The holy grail of bioengineering for regenerative medicine" CHICAGO --- The brave new world ...

Stem Cell Studies Approved for UF College of Medicine – Jacksonville

Researchers will focus on using patient’s own cells to improve health

29-Mar-2017 - A series of new stem cell studies that could potentially lead to breakthroughs in medicine has been approved to take place at the University of Florida College of Medicine – Jacksonville. The Institutional Review Board has given the go-ahead for John Murray, M.D., and his team to begin work on ...

Growing heart tissue on spinach leaves

28-Mar-2017 - Researchers face a fundamental challenge as they seek to scale up human tissue regeneration from small lab samples to full-size tissues, bones, even whole organs to implant in people to treat disease or traumatic injuries: how to establish a vascular system that delivers blood deep into the ...

Nanoengineers 3-D print biomimetic blood vessel networks

03-Mar-2017 - Nanoengineers at the University of California San Diego have 3D printed a lifelike, functional blood vessel network that could pave the way toward artificial organs and regenerative therapies. The new research, led by nanoengineering professor Shaochen Chen, addresses one of the biggest ...

Organ-on-a-chip mimics heart's biomechanical properties

(V

24-Feb-2017 - The human heart beats more than 2.5 billion times in an average lifetime. Now scientists at Vanderbilt University have created a three-dimensional organ-on-a-chip that can mimic the heart's amazing biomechanical properties. "We created the I-Wire Heart-on-a-Chip so that we can understand why ...