Acetylation: a Time-Keeper of glucocorticoid Sensitivity

Understanding the regulatory mechanism paves the way to enhance the effectiveness of anti-inflammatory therapies

02-Apr-2024 - Cortisol, also commonly known as the stress hormone, belongs to the family of glucocorticoids. In addition to its physiological function, synthetic derivatives of cortisol are also used as anti-inflammatory drugs. In the cell, the hormone acts by binding to the glucocorticoid receptor (GR), which ...

Proteomic profiling reveals innovation potential of new antibiotics

Research team intends to use proteomics to accelerate the development of new drugs

21-Oct-2020 - The fight against bacterial infections, especially those caused by resistant pathogens, is in full swing with the search for new antibiotic agents. The aim is to identify substances that attack the pathogens in a truly novel way. The team at the Center for Systems-Based Antibiotic Research ...

New targets for approved cancer drug discovered

11-Oct-2017 - Developing new drugs to treat cancer can be a painstaking process taking over a decade from start to Food and Drug Administration approval. Scientists are trying to develop innovative strategies to identify and test new drugs quicker and more efficiently. A team of researchers at Moffitt Cancer ...

Scientists isolate, culture elusive Yellowstone microbe

07-Jul-2016 - A microbial partnership thriving in an acidic hot spring in Yellowstone National Park has surrendered some of its lifestyle secrets to researchers at the Department of Energy’s Oak Ridge National Laboratory. Mircea Podar of ORNL’s Biosciences Division led a team that isolated the archaeon ...

Proteomics and precision medicine

09-Feb-2016 - As medical professionals search for new ways to personalize diagnosis and treatment of disease, a research team at the University of Iowa has already put into practice what may be the next big step in precision medicine: personalized proteomics. Proteomics is the large-scale analysis of all the ...

Agilent Technologies Awards Two Integrated-Biology Research Grants

25-Oct-2011 - Agilent Technologies Inc. announced the winners of the 2011 eMerging Insights grant program: Dr. Michael J. MacCoss of the University of Washington and Dr. Peter J. Park of Harvard University. Each will be awarded $75,000 toward their ongoing research on open source data-integration tools.The ...

Study reveals critical similarity between two types of do-it-all stem cells

13-Sep-2011 - Ever since human induced pluripotent stem cells were first derived in 2007, scientists have wondered whether they were functionally equivalent to embryonic stem cells, which are sourced in early-stage embryos.Both cell types have the ability to differentiate into any cell in the body, but their ...

Discovery of the secrets that enable plants near Chernobyl to shrug off radiation

17-Sep-2010 - Scientists are reporting discovery of the biological secrets that enable plants growing near the Chernobyl Nuclear Power Plant to adapt and flourish in highly radioactive soil — legacy of the 1986 nuclear disaster in the Ukraine. Their study, which helps solve a long-standing mystery, appears in ...

UF scientists discover clues to inflammatory disease

16-Jul-2010 - Immune system cells called macrophages spring into action to surround and destroy threats such as viruses or cancer cells. But sometimes the would-be protective response leads to persistent inflammation, which, in turn, can cause disease. Scientists don’t know exactly how macrophages cross the ...

Thermo Fisher Scientific Collaborates on Clinical Biomarker Research with Leading Proteomics Researcher in Luxembourg

26-Apr-2010 - Thermo Fisher Scientific Inc. and Professor Bruno Domon, director of the new Luxembourg Clinical Proteomics unit (LCP), announced a collaboration to develop workflows that overcome current bottlenecks in biomarker discovery and assay development for clinical proteomics research. The LCP is funded ...