Evotec, Inserm, Lille University Hospital and Inserm Transfert enter collaboration

Identification of novel therapeutic targets in obesity and metabolic diseases

31-May-2024 - Evotec SE announced that the Company entered a partnership with Inserm, the French National Institute of Health and Medical Research, Lille University Hospital and Inserm Transfert (the private subsidiary of Inserm) to identify novel therapeutic targets and diagnostic and prognostic markers in ...

NEOsphere Biotechnologies Partners with Kymera Therapeutics for Novel Molecular Glue Target Discovery

16-May-2024 - NEOsphere Biotechnologies GmbH, a German biotechnology company pioneering high-throughput proteomics to systematically build broad and unique portfolios of novel degrader targets at scale, announced a collaboration withKymera Therapeutics, Inc. focused on unlocking undrugged or poorly drugged ...

Testing how well biomarkers work

Researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy

02-May-2024 - Modern microscopy techniques make it possible to examine the inner workings of cells in astonishing detail. “We can now observe the arrangement and interaction of individual proteins under the microscope,” says Professor Ralf Jungmann, Chair of Molecular Physics of Life at LMU and Max Planck ...

Acetylation: a Time-Keeper of glucocorticoid Sensitivity

Understanding the regulatory mechanism paves the way to enhance the effectiveness of anti-inflammatory therapies

02-Apr-2024 - Cortisol, also commonly known as the stress hormone, belongs to the family of glucocorticoids. In addition to its physiological function, synthetic derivatives of cortisol are also used as anti-inflammatory drugs. In the cell, the hormone acts by binding to the glucocorticoid receptor (GR), which ...

Thianthrenium chemistry allows for reactivity switch of a nucleophilic amino acid into a versatile intermediate

Useful and broadly applicable tool in the field of chemical biology

03-Jan-2024 - Chemical diversification of proteins is an important concept in the study of biological processes and the complex structures of the proteins themselves. It involves using quick and mild reactions that selectively target a specific amino acid and therefore a building block of proteins. Cysteine is ...

Takara Bio and Eppendorf cooperate

Automation of Takara Bio’s Chemistries on Eppendorf’s Automated Pipetting Systems for Significantly Higher Efficiency

29-Aug-2023 - Takara Bio Inc. (Takara Bio) and Eppendorf SE, two renowned leaders in the life science industry, are pleased to announce their collaboration through a strategic co-marketing agreement. This partnership aims at jointly developing cutting-edge solutions to automate Takara Bio’s chemistries on ...

The Paradox of Thrombosis

18-Apr-2023 - Bears in hibernation and also paraplegic people spend months or even years lying almost motionless. In healthy people, however, bedriddenness is always accompanied by the risk of thrombosis. A paradox, but nevertheless an everyday occurrence. This contradiction has now been investigated by an ...

Novel spatial-omics technology enables investigation of diseases at their early stages

How can you trace a single diseased cell in an intact brain or a human heart?

28-Dec-2022 - The search resembles looking for a needle in a haystack. The teams of Ali Ertürk at Helmholtz Munich and LMU Munich and Matthias Mann at the Max Planck Institute of Biochemistry in Martinsried near Munich have now developed a new technology named DISCO-MS that solves the problem. DISCO-MS uses ...

Fighting Ovarian Cancer

Rhenium tricarbonyl complex with antitumor activity targets Fe-S cluster biogenesis

17-Oct-2022 - Metal-containing complexes have taken up center stage in the search for new cancer drugs that are as free of side effects as possible. In the journal Angewandte Chemie, a research team has now described how a very low dose of a rhenium metal complex interferes with cellular metabolism to such an ...

How bacteria adhere to cells: Basis for the development of a new class of antibiotics

04-Jul-2022 - The adhesion of bacteria to host cells is always the first and one of the decisivesteps in the development of infectious diseases. The purpose of this adhesion by infectious pathogens is first to colonize the host organism (i.e., the human body), and then to trigger an infection, which in the ...