A breakthrough in understanding COVID-19 proteins

Researchers have released a revolutionary database for molecular dynamics simulations

15-Jan-2024 - Designed to meet the urgent need for insights into the molecular intricacies of SARS-CoV-2 infection, BioExcel-CV19 is a repository for Molecular Dynamics (MD) simulations. Researchers at IRB Barcelona, led by Dr. Modesto Orozco, have built this database including key flexibility information ...

CSIC researchers identify a new class of antivirals against covid-19

New antivirals act by blocking virus entry into the host cell through interaction with the 'spike' protein

07-Aug-2023 - Researchers from the Consejo Superior de Investigaciones Científicas at the Instituto de Química Médica (IQM-CSIC), the Instituto de Biología Integrativa de Sistemas (I2SysBio-CSIC-UV) and the Instituto de Biomedicina de Valencia (IBV-CSIC), members of the Plataforma Temática Interdisciplinar ...

CSIC researchers propose a new therapeutic strategy to treat retinal degeneration

Study has revealed how to reactivate with drugs a defense mechanism that prevents toxic accumulation of proteins in cells

14-Sep-2022 - A study by the Spanish National Research Council (CSIC) has discovered a molecular mechanism that suggests a new therapeutic strategy to treat retinitis pigmentosa, a type of retinal degeneration that affects one in every 4,000 people. The work, carried out in rodents, has been published in the ...

Strategy designed to identify therapeutic targets in triple-negative breast cancer

Localizes proteins in the membrane of tumor cells and then targets them in a specific way.

26-Apr-2022 - Research led by the Cancer Research Center (CIC), a joint center of the Spanish National Research Council (CSIC) and the University of Salamanca (USAL), has described a strategy for identifying proteins in the membrane of tumor cells and then attacking these cells using specific antibodies ...

Abundant ‘secret doors’ on human proteins could reshape drug discovery

Identification of hidden vulnerabilities on surface of ‘undruggable’ proteins could transform treatment of disease

11-Apr-2022 - The number of potential therapeutic targets on the surfaces of human proteins is much greater than previously thought, according to the findings of a new study in the journal Nature. A ground-breaking new technique developed by researchers at the Centre for Genomic Regulation (CRG) in Barcelona ...

Mechanism governing cell division in one of the most lethal superbugs unveiled

A study has unraveled the cell division mechanism of Staphylococcus aureus, one of the most virulent antibiotic-resistant bacteria

25-Mar-2022 - CSIC researchers have unveiled the mechanism that governs cell division in one of the most lethal superbugs,Staphylococcus aureus (Staphylococcus aureus). The finding delves into the internal mechanism of bacterial cell division, a key process for the spread of infections, and opens a way to ...

Delve into the behavior of cohesins

22-Oct-2013 - Cohesins are protein complexes that join the two copies of each chromosome—called sister chromatids—to ensure that they are shared fairly between the daughter cells during cell division. In this way, each daughter cell receives exactly the same genetic information from the parent cell. Pds5 is a ...

Electrochemical sensor for coeliac disease promises easy diagnosis of gluten allergy

07-Mar-2013 - Researchers have developed the first example of an electrochemical immunosensor for the diagnosis of coeliac disease – a genetically determined specific immune response to the antigens present in gluten. Electrochemical immunosensors (EIs) are interesting alternatives to conventional ...

Researchers design a tool to induce controlled suicide in human cells

Scientists will use it to analyze the stress responses used by cells to solve genomic errors, and also to identify targets of therapeutic interest

21-Dec-2009 - When cells accumulate excessive errors in the proteins they produce, apoptosis is activated, that is to say, a cell suicide programme; however, beforehand the cells attempt to rectify the problem through a number of rescue responses. Scientists know only the general outline of the mechanisms ...

Granada researchers demonstrate the effectiveness of proteins found in pulses to prevent colon cancer

21-Aug-2009 - Scientists of the Estación Experimental del Zaidín (EEZ) Granada centre, attached to the CSIC, have proven that a group of proteins present in pulses are useful to prevent gastrointestinal diseases and, specially, to prevent colon cancer. They are leguminous proteins of the Bowman-Birk family ...