CSIC researchers identify a new class of antivirals against covid-19

New antivirals act by blocking virus entry into the host cell through interaction with the 'spike' protein

07-Aug-2023 - Researchers from the Consejo Superior de Investigaciones Científicas at the Instituto de Química Médica (IQM-CSIC), the Instituto de Biología Integrativa de Sistemas (I2SysBio-CSIC-UV) and the Instituto de Biomedicina de Valencia (IBV-CSIC), members of the Plataforma Temática Interdisciplinar ...

New mechanism of immunity against RNA virus discovered in plants

Scientists at the Institute of Molecular and Cellular Plant Biology demonstrate that proteins called ECTs act against viruses such as alfalfa and potato mosaic virus.

04-Aug-2023 - A research group from the Instituto de Biología Molecular y Celular de Plantas (IBMCP), a joint center of the Consejo Superior de Investigaciones Científicas (CSIC) and the Universitat Politècnica de València (UPV), has discovered that a group of plant proteins belonging to a family called ECTs ...

New proteins that mimic immunoglobulins in antibodies could lead to more effective drug design

CSIC researchers participate in a study that uses computational design to obtain proteins with better properties and a more precise mechanism of action

07-Oct-2022 - Researchers from the Spanish National Research Council (CSIC) and the Institute for Protein Design have co-designed and created new proteins, non-existent in nature, with structures that mimic the immunoglobulins of antibodies, which are the proteins used by the immune system to identify and ...

CSIC researchers propose a new therapeutic strategy to treat retinal degeneration

Study has revealed how to reactivate with drugs a defense mechanism that prevents toxic accumulation of proteins in cells

14-Sep-2022 - A study by the Spanish National Research Council (CSIC) has discovered a molecular mechanism that suggests a new therapeutic strategy to treat retinitis pigmentosa, a type of retinal degeneration that affects one in every 4,000 people. The work, carried out in rodents, has been published in the ...

Two proteins identified that modulate skin stem cell behavior

The alteration of this function favors the appearance of skin tumors, so this finding may help in the development of antitumor therapies

08-Jun-2022 - A study carried out at the Cancer Research Center, a joint center of the Spanish National Research Council (CSIC) and the University of Salamanca (USAL), has identified two proteins that modulate the behavior of skin stem cells. The alteration of this function favors the appearance of skin ...

Strategy designed to identify therapeutic targets in triple-negative breast cancer

Localizes proteins in the membrane of tumor cells and then targets them in a specific way.

26-Apr-2022 - Research led by the Cancer Research Center (CIC), a joint center of the Spanish National Research Council (CSIC) and the University of Salamanca (USAL), has described a strategy for identifying proteins in the membrane of tumor cells and then attacking these cells using specific antibodies ...

Mechanism governing cell division in one of the most lethal superbugs unveiled

A study has unraveled the cell division mechanism of Staphylococcus aureus, one of the most virulent antibiotic-resistant bacteria

25-Mar-2022 - CSIC researchers have unveiled the mechanism that governs cell division in one of the most lethal superbugs,Staphylococcus aureus (Staphylococcus aureus). The finding delves into the internal mechanism of bacterial cell division, a key process for the spread of infections, and opens a way to ...

Discovery of a protein that protects the brain from Alzheimer's disease

It is the LRP3 protein, which lowers the levels of two proteins involved in the formation of plaques in the brains of people with Alzheimer's disease.

04-Mar-2022 - A team of CSIC researchers has shown that a little-known protein called LRP3 controls the levels of beta-amyloid, the protein that accumulates in the brains of people with Alzheimer's disease, forming the plaques that characterize this disease. This protein could be a new therapeutic target and a ...

Bigger, better, faster

3D structure reveals protein’s Swiss-army knife strategy

28-Oct-2013 - The molecular machine that makes essential components of ribosomes – the cell’s protein factories – is like a Swiss-army knife, researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and the Centro de Investigaciones Biológicas in Madrid, Spain, have found. By ...

Granada researchers demonstrate the effectiveness of proteins found in pulses to prevent colon cancer

21-Aug-2009 - Scientists of the Estación Experimental del Zaidín (EEZ) Granada centre, attached to the CSIC, have proven that a group of proteins present in pulses are useful to prevent gastrointestinal diseases and, specially, to prevent colon cancer. They are leguminous proteins of the Bowman-Birk family ...