Power-to-vitamins: microbes produce folate from simple basic ingredients

Biotechnology team obtains valuable byproduct in protein produc-tion

16-Sep-2024 - Take some carbon dioxide, hydrogen, and oxygen plus electricity from renewable sources – a bacterium and baker’s yeast need little more to produce proteins for human nourishment and the essential vitamin B9 in a conventional laboratory bioreactor system. This was the result achieved by a research ...

AI tailors artificial DNA for future drug development

DNA molecules made-to-order: “What otherwise takes years is now shortened to weeks or days”

25-Nov-2022 - With the help of artificial intelligence, researchers at Chalmers University of Technology, Sweden, have succeeded in designing synthetic DNA that controls the cells' protein production. The technology can contribute to the development and production of vaccines, drugs for severe diseases, as ...

How SARS-CoV-2 takes over the cell's protein factory

“We've discovered three possible approaches to antiviral treatments”

15-Mar-2022 - The question of how the Covid virus takes over host cells and suppresses the body's defences has been the subject of much debate. Now a research team led by Marina Chekulaeva at the MDC has pinpointed the crucial mechanism involved. It's over two years since the outbreak of the coronavirus ...

Rear-end Collision on the “Ribosome Highway”

Researchers identify bacterial protein that senses and rescues “stalled” ribosomes

14-Mar-2022 - As a molecular machine found in the cells of all organisms, the ribosome is responsible for making new proteins. It reads the blueprint for a certain protein on a messenger molecule – known as messenger RNA (mRNA) – and then converts this information into new proteins. For a number of reasons, ...

New method to produce chemically modified mRNA developed

Chemists describes a new synthetically produced, highly modified messenger RNA that allows cells to more efficiently produce proteins

07-Mar-2022 - In a recent study, the research group at the University of Cologne’s Institute of Organic Chemistry led by Professor Dr Stephanie Kath-Schorr describes a novel method for the enzymatic production of synthetic messenger RNA (mRNA). While natural base modifications of mRNA are already being used – ...

Mechanism discovered how the coronavirus hijacks the cell

A starting point for vaccine and drug development

15-Sep-2020 - Researchers at ETH Zurich and the University of Bern have discovered a mechanism by which the corona virus manipulates human cells to ensure its own replication. This knowledge will help to develop drugs and vaccines against the corona virus. Like a pirate hijacking a ship, a virus takes control ...

Machine Learning to increase biotechnology-based protein production

21-May-2019 - In a research co-operation, researchers of the Paul-Ehrlich-Institut (PEI) have developed a mathematical model which allows more accurate forecasts and improved output in the biotechnology-based protein synthesis in host organism. The new method offers many and varied applications in ...

It's all in the code

Protein production efficiency can be predicted by gene sequence

06-Feb-2019 - Today, thousands of databases with biological data are publicly available. They include data on gene and protein sequences and detailed measurements of different cellular parameters, such as the exact quantities of all proteins produced and degraded by a given cell in various experimental ...

New platform based on biology and nanotechnology carries mRNA directly to target cells

Effective passage for therapies treating cancer and other diseases

31-Oct-2018 - Delivering an effective therapeutic payload to specific target cells with few adverse effects is considered by many to be the holy grail of medical research. A new Tel Aviv University study explores a biological approach to directing nanocarriers loaded with protein "game changers" to specific ...

New drug candidates reverse drug resistance in multiple myeloma in preclinical models

31-Oct-2018 - In an article Medical University of South Carolina investigators report that a new compound enhances the efficacy of proteasome inhibitors (PIs), the standard-of-care for the treatment of multiple myeloma (MM), in cell culture and in preclinical models. The efficacy and safety of the novel ...