Machine Learning to increase biotechnology-based protein production

21-May-2019 - In a research co-operation, researchers of the Paul-Ehrlich-Institut (PEI) have developed a mathematical model which allows more accurate forecasts and improved output in the biotechnology-based protein synthesis in host organism. The new method offers many and varied applications in ...

How estrogen regulates gene expression

28-Aug-2017 - Estrogen hormones regulate gene expression. They achieve this by first binding to estrogen receptor in the cell nucleus, which triggers the recruitment of different molecules called coactivators in specific order. In a study a team of researchers at Baylor College of Medicine, the University of ...

Scientists seek to engineer chatter among cells

24-Jul-2017 - Communities of cells communicate to coordinate their actions, but how do they coordinate with other communities? Scientists at Rice University and the University of Houston are preparing to find out. Rice synthetic biologist Matthew Bennett and University of Houston mathematician Krešimir Josić ...

Overloading of protein localization triggers cellular defects

07-Mar-2017 - Researchers at Okayama University report how the overloading of protein transport mechanisms affects cell functioning. Over-expression of different types of target proteins leads to cellular growth defects, and the mechanism for transporting proteins out of a cell nucleus has the lowest ...

A close look at sharp vision in eye structure seen only in humans and other primates

24-Feb-2017 - Vision scientists have uncovered some of the reasons behind the unusual perceptual properties of the eye's fovea. Only humans and other primates have this dimple-like structure in their retinas. It is responsible for visual experiences that are rich in colorful spatial detail. Figuring out how ...

Researchers uncover protein-based “cancer signature”

06-Dec-2016 - A research team at the University of Basel’s Biozentrum has investigated the expression of ribosomal proteins in a wide range of human tissues including tumors and discovered a cancer type specific signature. As the researchers report in “Genome Biology” this “cancer signature” could potentially ...

Enough is enough

Stem cell factor Nanog knows when to slow down

28-Nov-2016 - The transcription factor Nanog plays a crucial role in the self-renewal of embryonic stem cells. Previously unclear was how its protein abundance is regulated in the cells. Researchers at the Helmholtz Zentrum München and the Technical University of Munich, working in collaboration with ...

Novel gene variants identified in male breast cancer

03-Mar-2016 - Male breast cancer (MBC) is a very rare tumor type, occurring in just 1% of all breast cancer cases, and the underlying genetic causes and treatment of MBC is not well understood. In a paper researchers from Italy and the U.S. describe novel genetic variants found in a hormone receptor positive ...

Mount Sinai researchers develop tool to determine function of MicroRNAs

11-Dec-2015 - As microRNA biology has been implicated in everything from the development of cancer to virus infections, a new tool developed by scientists at the Icahn School of Medicine at Mount Sinai holds tremendous potential to develop new therapies that involve these small regulatory fragments of RNA. ...

The Gene Center at Ludwig-Maximilians-Universität München and ExpreS2ion Biotechnologies Enter a Licensing Agreement

25-Feb-2015 - ExpreS2ion Biotechnologies announced the signature of a research license agreement to provide the Gene Center at Ludwig-Maximilians-Universität München with access to its Drosophila Schneider-2 cell-based technology platform - ExpreS2 - for recombinant protein production. The stable, non-lytic ...