Synthesizing fine chemicals: Technological Advance in Production of Pharmaceuticals

04-Oct-2024 - Production of fine chemicals such as those used in pharmaceuticals is typically complex and laborious. An interdisciplinary team of Fraunhofer researchers worked together across different projects to devise a method modeled on a cascade, in which multiple successive stages of synthesis proceed ...

Klaus Grohe Prize goes to Yimon Aye

50,000 euros for groundbreaking research into cell communication

28-Jun-2024 - Professor Dr. Yimon Aye, École polytechnique fédérale de Lausanne (EPFL), Switzerland, will be awarded the Klaus Grohe Prize 2024. The award, worth 50,000 euros, is one of the most highly endowed prizes for medicinal chemistry in Europe. It is awarded by the Klaus Grohe Foundation, which is part ...

A better route to benzocyclobutenes, sought-after buildingblocks for drugs

Scripps Research chemists devise a new, C-H activation-based method for the synthesis of BCBs

16-May-2023 - Scripps Research chemists have solved a long-standing problem in the field of pharmaceutical chemistry with a relatively simple and controllable method for making benzocyclobutenes (BCBs)—a class of reactive compounds that are highly valued as building blocks for drug molecules, but have been ...

WITec announces Paper Award 2022 winners

The prizes go to scientists from the US, Germany and China

10-Aug-2022 - The WITec Paper Awards 2022 have been given to scientists from the US, Germany and China, recognizing their work in cement chemistry, pharmacy and methane hydrate chemistry. Every year, the WITec Paper Award highlights three scientific publications that contain data acquired with a WITec ...

Breakthrough in the production of three-dimensional molecular structures

New dimensions in organic chemistry through light-mediated synthesis

07-Apr-2021 - A major goal of organic and medicinal chemistry in recent decades has been the rapid synthesis of three-dimensional molecules for the development of new drugs. These drug candidates exhibit a variety of improved properties compared to predominantly flat molecular structures, which are reflected ...

Researchers at the forefront of developing machine learning methods for chemical discovery

Machine learning to help identify drug candidates

23-Oct-2020 - Prof. Alexandre Tkatchenko and his research team at the University of Luxembourg have been awarded grants totalling 500,000 euros to conduct research in the emerging field of machine learning methods for chemical discoveries. The discovery and formulation of new drugs, antivirals, antibiotics and ...

Utilizing CRISPR for better antibiotics

Drug screening with Mobile-CRISPRi

15-Jan-2019 - A University of Wisconsin-Madison researcher and his collaborators at the University of California, San Francisco have repurposed the gene-editing tool CRISPR to study which genes are targeted by particular antibiotics, providing clues on how to improve existing antibiotics or develop new ...

New drug candidates reverse drug resistance in multiple myeloma in preclinical models

31-Oct-2018 - In an article Medical University of South Carolina investigators report that a new compound enhances the efficacy of proteasome inhibitors (PIs), the standard-of-care for the treatment of multiple myeloma (MM), in cell culture and in preclinical models. The efficacy and safety of the novel ...

ChemMaps lets researchers navigate the chemical universe

06-Jun-2018 - Researchers from North Carolina State University have created a new online service - ChemMaps - that allows users to interactively navigate the chemical space of over 8,000 drugs and 47,000 environmental compounds in 3D and real time. ChemMaps is designed to be a central resource for students and ...

Google provides open source library for quantum chemistry

Platform-independent solution to integrate future developments

26-Oct-2017 - Since physicists have been dealing with the theoretical description of molecules, the solving of quantum mechanical equations has been a major obstacle. This is supposed to be a thing of the past with the release of an open source based system. Google has introduced such a system to the public ...