Green chemistry needs more green toxicology

Sustainable bioeconomy: Development of environmentally friendly bio-shampoos and plant protection agent technologies

16-Feb-2022 - With the early assessment of sustainable, newly developed chemicals and products it is possible to assess a potential risk of toxic substances being released at a later point in product cascades. This has been revealed in a proof-of-concept study jointly coordinated by Goethe University Frankfurt ...

Fungus produces highly effective surfactant

26-Jun-2019 - Mortierella alpina lives in the soil and likes to keep cool. This fungus, which belongs to the zygomycetes, grows best at temperatures of 10 to 15°C and occurs mainly in alpine or arctic habitats. In biotechnology, the fungus has been used for the large-scale production of polyunsaturated fatty ...

Cracking colibactin's code

Examining a compound damaging DNA to understand its connection to cancer

19-Feb-2019 - For more than a decade, scientists have worked to understand the connection between colibactin, a compound produced by certain strains of E. coli, and colorectal cancer, but have been hampered by their inability to isolate the compound. So Emily Balskus instead decided to focus on the mess it ...

New insight into cell receptors opens the way for tailored cancer drugs

12-Feb-2019 - New research on how cancer mutations influence a certain type of receptor on the cell membrane opens the way for the development of tailored drugs for certain cancers, such as rectal cancer and lung cancer. This according to researchers at Sweden's Karolinska Institutet and Uppsala University, ...

Revealing the path of a metallodrug in a breast cancer cell

05-Feb-2019 - Some types of cancer cannot be treated with classical chemotherapy. Scientists from Inserm, CNRS, Sorbonne University, PSL university, University Grenoble Alpes and ESRF, the European Synchrotron, are working on a metallorganic molecule as an antitumor drug. Their research has given thorough ...

New drug candidates reverse drug resistance in multiple myeloma in preclinical models

31-Oct-2018 - In an article Medical University of South Carolina investigators report that a new compound enhances the efficacy of proteasome inhibitors (PIs), the standard-of-care for the treatment of multiple myeloma (MM), in cell culture and in preclinical models. The efficacy and safety of the novel ...

3D 'organ on a chip' could accelerate search for new disease treatments

30-Oct-2018 - Researchers have developed a three-dimensional 'organ on a chip' which enables real-time continuous monitoring of cells, and could be used to develop new treatments for disease while reducing the number of animals used in research. The device, which incorporates cells inside a 3D transistor made ...

An effective approach to optimizing medicinal molecules

16-Aug-2018 - The search for new medicinal molecules with predetermined properties is a rather complex, expensive and time-consuming process, especially in oncology. Modern science allows us to accelerate this search through the use of computer technology and the introduction of automated processes. In the ...

New informatics tool makes the most of genomic data

13-Jul-2018 - The rise of genomics, the shift from considering genes singly to collectively, is adding a new dimension to medical care; biomedical researchers hope to use the information contained in human genomes to make better predictions about individual health, including responses to therapeutic drugs. A ...

Transport molecule has unexpected role

18-Jun-2018 - UT Southwestern researchers recently reported a basic science finding that might someday lead to better treatments for neurodegenerative diseases like a hereditary form of Lou Gehrig's disease. In a study, Dr. Yuh Min Chook, Professor of Pharmacology and Biophysics, and Dr. Michael Rosen, Chair ...