A better route to benzocyclobutenes, sought-after buildingblocks for drugs

Scripps Research chemists devise a new, C-H activation-based method for the synthesis of BCBs

16-May-2023 - Scripps Research chemists have solved a long-standing problem in the field of pharmaceutical chemistry with a relatively simple and controllable method for making benzocyclobutenes (BCBs)—a class of reactive compounds that are highly valued as building blocks for drug molecules, but have been ...

New drug candidates reverse drug resistance in multiple myeloma in preclinical models

31-Oct-2018 - In an article Medical University of South Carolina investigators report that a new compound enhances the efficacy of proteasome inhibitors (PIs), the standard-of-care for the treatment of multiple myeloma (MM), in cell culture and in preclinical models. The efficacy and safety of the novel ...

ChemMaps lets researchers navigate the chemical universe

06-Jun-2018 - Researchers from North Carolina State University have created a new online service - ChemMaps - that allows users to interactively navigate the chemical space of over 8,000 drugs and 47,000 environmental compounds in 3D and real time. ChemMaps is designed to be a central resource for students and ...

Synthesis of medicinally privileged heterocycles through dielectric heating

10-Mar-2017 - Heterocyclic compounds are enormously crucial in various industries including food, agricultural, cosmetics and pharmaceuticals. Heterocyclic pharmacophores are one of the main chemical components in drug discovery research. A report in 2013 claims that four out of six and nine out of twenty one ...

Catalyst adds fluorine-containing groups to make new compounds

25-Jan-2017 - Drugs that contain one or more fluorine atoms tend to be more stable, more powerful, and easier for the body to absorb. For those reasons, drug developers would like to be able to incorporate fluorine or a fluorine-containing unit known as trifluoromethyl into new experimental drugs, but this has ...

Manipulating signals in bacteria could reduce illnesses

13-Jan-2017 - The University of Illinois at Chicago College of Pharmacy has received a five-year, $1.25 million federal grant to continue its research into how bacteria that cause streptococcal infections can be manipulated. By studying the chemical signals of bacteria, Michael Federle, associate professor of ...

New technique that could speed drug development

05-Dec-2016 - Synthesizing useful new compounds is what pharmaceutical discovery and development is all about. Researchers at the School of Science at Indiana University-Purdue University Indianapolis have devised a method to substantially speed up the process. The IUPUI chemists have developed and tested a ...

Two antibiotics fight bacteria differently than thought

03-Nov-2016 - Two widely prescribed antibiotics -- chloramphenicol and linezolid -- may fight bacteria in a different way from what scientists and doctors thought for years, University of Illinois at Chicago researchers have found. Instead of indiscriminately stopping protein synthesis, the drugs put the ...

Experimental antibiotic treats deadly MRSA infection

16-Jun-2016 - A new experimental antibiotic developed by a team of scientists at Rutgers University successfully treats the deadly MRSA infection and restores the efficacy of a commonly prescribed antibiotic that has become ineffective against MRSA. In research Rutgers scientists say that the combination of ...

Dendrimer technology gets a grip on cell proteins, could improve cancer treatment

13-Nov-2015 - Purdue researchers have devised a way to capture the finer details of complex cell processes by using tiny synthetic particles known as dendrimers, a technology that could lead to more targeted treatment for cancer. A precise understanding of how cells engulf small particles, a process known as ...