A better route to benzocyclobutenes, sought-after buildingblocks for drugs

Scripps Research chemists devise a new, C-H activation-based method for the synthesis of BCBs

16-May-2023 - Scripps Research chemists have solved a long-standing problem in the field of pharmaceutical chemistry with a relatively simple and controllable method for making benzocyclobutenes (BCBs)—a class of reactive compounds that are highly valued as building blocks for drug molecules, but have been ...

New drug candidates reverse drug resistance in multiple myeloma in preclinical models

31-Oct-2018 - In an article Medical University of South Carolina investigators report that a new compound enhances the efficacy of proteasome inhibitors (PIs), the standard-of-care for the treatment of multiple myeloma (MM), in cell culture and in preclinical models. The efficacy and safety of the novel ...

BioAscent receives funding for its integrated drug discovery services

28-Jun-2018 - BioAscent has secured £1.6m in funding from Maven Capital Partners (“Maven”). The investment will facilitate BioAscent’s growth through its unique offering of integrated drug discovery, and compound management services, as well as the Compound Cloud library of lead-like pharma compounds, from its ...

ChemMaps lets researchers navigate the chemical universe

06-Jun-2018 - Researchers from North Carolina State University have created a new online service - ChemMaps - that allows users to interactively navigate the chemical space of over 8,000 drugs and 47,000 environmental compounds in 3D and real time. ChemMaps is designed to be a central resource for students and ...

Selcia joins Eurofins Group

26-Jan-2018 - Selcia Limited announces that it has been acquired by Eurofins Scientific, a global leader in analytical testing and pharma discovery services. The acquisition of Selcia provides Eurofins with an entry into the custom radiolabelling and innovative pre-clinical, integrated drug discovery services ...

Eurofins opens new faciltiy in Livingston

28-Sep-2017 - Eurofins Scientific (EUFI.PA), a world leader in bioanalytical testing, has today opened a new pharmaceutical chemistry, microbiology and water microbiology facility in Livingston, Scotland, following a £4 million investment. A plaque marking the opening of the laboratories at Brucefield Industry ...

Streamlined process opens drug development to a new class of steroids

27-Sep-2017 - Researchers at Dartmouth College have developed a technique to produce synthetic steroids that could pave the way for a cascade of new drug discoveries. The process facilitates access to rare, mirror-image isomers of naturally occurring steroid structures. The technique, based on a series of new ...

Common, edible mushroom has potential to kill one type of leukemia cell

09-Aug-2017 - An edible, shaggy-looking mushroom contains a protein that is a potent killer of a certain leukemia cell, a group of University of Florida researchers has found. The Coprinus comatus mushroom, commonly known as the lawyer’s wig or shaggy mane, killed human T-cell leukemia cells during laboratory ...

Exscientia enters strategic drug discovery collaboration with GSK

Pre-clinical collaboration focused on up to 10 targets

03-Jul-2017 - Exscientia, a company for Artificial Intelligence (AI)-driven drug discovery, announces it has entered into a strategic drug discovery collaboration with GlaxoSmithKline (GSK). During this collaboration, Exscientia will apply its AI enabled platform and combine this with the expertise of GSK, in ...

State-of-the-art text mining technologies for chemistry

23-Jun-2017 - The Biological Text Mining Unit at the Spanish National Cancer Research Centre (CNIO) together with with researchers at the Center for Applied Medical Research (CIMA), of the University of Navarra, in Pamplona, and the Barcelona Supercomputing Centre (BSC-CNS) have published the first exhaustive ...