A Second Chance for New Antibiotic Agent

Drug candidate rejected 20 years ago may now be more selective thanks to new research

22-May-2024 - Twenty years ago, a drug candidate was rejected due to its side effects. Researchers have now figured out how to potentially make a successor molecule more selective. An increasing number of bacteria have become resistant to many commonly used antibiotics. Researchers from Bochum have discovered ...

Start-up Lifespin launches therapeutic drug monitoring of anti-infectives

An important step towards integrating precision medicine and antibiotic resistance control

07-Dec-2023 - Lifespin GmbH, an emerging company in the field of precision health information, introduces its Therapeutic Drug Monitoring (TDM) of anti-infectives. This Laboratory Development Test (LDT) represents a significant advance in the field of personalized medicine by enabling individualized approaches ...

A miniature magnetic resonance imager made of diamond

Quantum sensors make microscale NMR spectroscopy possible

23-Oct-2023 - The development of tumors begins with miniscule changes within the body's cells; ion diffusion at the smallest scales is decisive in the performance of batteries. Until now the resolution of conventional imaging methods has not been high enough to represent these processes in detail. A research ...

Researchers decode new antibiotic

Combined attack minimizes resistance development

24-Aug-2023 - More and more bacterial pathogens are developing resistance. There is an increasing risk that common drugs will no longer be effective against infectious diseases. Researchers from the University of Bonn, the German Center for Infection Research (DZIF), Utrecht University (Netherlands), ...

Inflammation Values by Spectrometry

Quantifying acute-phase inflammation proteins by NMR

27-Jul-2023 - The analysis of all small molecules in an organism (the metabolome) has huge potential for medical diagnostics. A German research team is investigating this with nuclear magnetic resonance spectrometry (NMR). In a study recently published in Angewandte Chemie, they quantified acute-phase proteins ...

Under control to the very end – how our cells kill themselves

Using highly sensitive microscopes and NMR spectroscopy, the mechanism has been elucidated down to the level of individual atoms

24-May-2023 - Every day, millions of cells die in our body. Other than generally assumed, cells do not simply burst at the end of their lives but rather, a specific protein serves as a breaking point for cell membrane rupture. Researchers at the University of Basel have now been able to elucidate the exact ...

Less risk, less costs: Portable spectroscopy devices could soon become real

New approach to enable measurements without strong magnetic fields

06-Sep-2022 - Nuclear magnetic resonance (NMR) is an analytical tool with a wide range of applications, including the magnetic resonance imaging that is used for diagnostic purposes in medicine. However, NMR often requires powerful magnetic fields to be generated, which limits the scope of its use. Researchers ...

Pimp my Spec: Upgrade for Magnetic Resonance Methods with a 1,000-fold Amplifier

Atomistically accurate description of proteins at native concentrations can help to better understand the process of cell proliferation to tumour growth

15-Aug-2022 - Researchers determine the structure and dynamics of proteins using NMR (Nuclear Magnetic Resonance) spectroscopy. Until now, however, much higher concentrations were necessary for in-vitro measurements of the biomolecules in solution than found in our body's cells. An NMR method enhanced by a ...

Magnetic resonance makes the invisible visible

Hyperpolarised water boosts signal intensities of proteins, DNA, and membranes

20-May-2022 - A small group of researchers including Dennis Kurzbach from the Faculty of Chemistry of the University of Vienna just published in "Nature Protocols" an advanced NMR (Nuclear Magnetic Resonance) method to monitor fast and complicated biomolecular events such as protein folding. For example, ...

DNAzymes – how active DNA molecules with therapeutic potential work

28-Dec-2021 - DNAzymes are precision biocatalysts that destroy unwanted RNA molecules. However, major obstacles to their use in medicine remain. Together with Jülich Research Centre (FZJ) and the University of Bonn, a research team from Heinrich Heine University Düsseldorf (HHU) has investigated with atomic ...