A promising investigational therapeutic monoclonal antibody to treat chronic hepatitis B and D infections

08-Aug-2023 - Affecting hundreds of millions of people, chronic hepatitis B is a widespread global health problem for which there is as yet no cure. In a preclinical study involving the German Center for Infection Research (DZIF), Heidelberg University Hospital, University Medical Center Hamburg-Eppendorf and ...

New proteins that mimic immunoglobulins in antibodies could lead to more effective drug design

CSIC researchers participate in a study that uses computational design to obtain proteins with better properties and a more precise mechanism of action

07-Oct-2022 - Researchers from the Spanish National Research Council (CSIC) and the Institute for Protein Design have co-designed and created new proteins, non-existent in nature, with structures that mimic the immunoglobulins of antibodies, which are the proteins used by the immune system to identify and ...

€ 1 Million Research Grant Awarded for the First Time

Merck awarded a grant known as the Future Insight Prize for the first time

11-Jul-2019 - Merck awarded a grant known as the Future Insight Prize for the first time. Pardis Sabeti, Harvard University and the Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA, and James Crowe, Vanderbilt University Medical Center, Nashville, Tennessee, USA, were recognized for their ...

Investigational monoclonal antibody to treat Ebola is safe in adults

28-Jan-2019 - The investigational Ebola treatment mAb114 is safe, well-tolerated, and easy to administer, according to findings from an early-stage clinical trial. Eighteen healthy adults received the monoclonal antibody as part of a Phase 1 clinical trial that began in May 2018 at the National Institutes of ...

Machine-learning driven findings uncover new cellular players in tumor microenvironment

Involvement of adipocytes in nivolumab response in ipilimumab resistant melanoma patients

18-Oct-2018 - New findings presented by CytoReason reveals possible new cellular players in the tumor microenvironment that could impact the treatment process for the most in-need patients - those who have already failed to respond to ipilimumab (anti-CTLA4) immunotherapy. Once validated, the findings could ...

Cancer: Tumor transition states

23-Apr-2018 - Researchers at the Université libre de Bruxelles, ULB define for the first time the tumor transition states occurring during cancer progression and identify the tumor cell populations responsible for metastasis. Tumor heterogeneity describes the differences between different cells within a given ...

Monoclonal Antibodies Against Zika Show Promise in Monkey Study

09-Oct-2017 - Using blood samples from an individual previously infected with Zika virus, scientists funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have developed an antibody-based Zika virus therapeutic that protected monkeys from ...

BioMed X and Merck launch two new projects in the fields of cancer research and biologics manufacturing

09-Jun-2017 - BioMed X announces the launch of two new global calls for application together with Merck KGaA in Darmstadt in the fields of RNA splicing in cancer and engineering of high-performance production cell lines. Talented young scientists from the world’s top universities and research institutions are ...

New method enables creation of better therapeutic antibodies

15-Mar-2017 - Antibodies are the foot soldiers of our immune system. These specialized, Y-shaped proteins attach to bacteria and viruses, where they either block the pathogen's activity directly, or signal the immune system's cells to destroy the invader. The second function--the ability to target invaders for ...

Early study finds antibody that ‘neutralizes’ Zika virus

09-Nov-2016 - Researchers at Vanderbilt University Medical Center and Washington University School of Medicine in St. Louis have isolated a human monoclonal antibody that in a mouse model “markedly reduced” infection by the Zika virus. The antibody, called ZIKV-117, also protected the fetus in pregnant mice ...