Testing how well biomarkers work

Researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy

02-May-2024 - Modern microscopy techniques make it possible to examine the inner workings of cells in astonishing detail. “We can now observe the arrangement and interaction of individual proteins under the microscope,” says Professor Ralf Jungmann, Chair of Molecular Physics of Life at LMU and Max Planck ...

Microscopy: Overcoming the traditional resolution limit for the fast co-tracking of molecules

Researchers have developed an innovative method to simultaneously track rapid dynamic processes of multiple molecules at the molecular scale

16-Feb-2024 - Processes within our bodies are characterized by the interplay of various biomolecules such as proteins and DNA. These processes occur on a scale often within a range of just a few nanometers. Consequently, they cannot be observed with fluorescence microscopy, which has a resolution limit of ...

WildDISCO: Visualizing Whole Bodies in Unprecedented Detail

AI Integration: Predicting Disease Progression Without the Use of Animal Models in Research

12-Jul-2023 - Researchers developed a new method called wildDISCO that uses standard antibodies to map the entire body of an animal using fluorescent markers. This revolutionary technique provides detailed 3D maps of structures, shedding new light on complex biological systems and diseases. WildDISCO has the ...

Ångström-Resolution Fluorescence Microscopy

This innovation is poised to usher in a paradigm shift in our approach to study biological systems with thus far unprecedented detail

05-Jun-2023 - A breakthrough in fluorescence microscopy has been achieved by the research group of Ralf Jungmann at the Max Planck Institute of Biochemistry (MPIB) and Ludwig-Maximilians-Universität (LMU) Munich. The team developed Resolution Enhancement by Sequential Imaging (RESI), a revolutionary technique ...

Microscopy: highest resolution in three dimensions

Researchers have developed a super-resolution microscopy method for the rapid differentiation of molecular structures in 3D.

15-Mar-2023 - Super-resolution microscopy methods are essential for uncovering the structures of cells and the dynamics of molecules. Since researchers overcame the resolution limit of around 250 nanometers (and winning the 2014 Nobel Prize in Chemistry for their efforts), which had long been considered ...

Point-of-care diagnostics: New methods for detecting single molecules

Pathogen-specific detection: Even one single DNA molecule is enough

04-Nov-2021 - Resistance to antibiotics is on the rise worldwide. Researchers at the Fraunhofer Institute for Physical Measurement Techniques IPM alongside the Ludwig Maximilian University of Munich have developed a process for rapidly detecting multidrug-resistant pathogens. The unique feature: Even one ...

Transparent human organs allow 3D maps at the cellular level

17-Feb-2020 - For the first time, researchers managed to make intact human organs transparent. Using microscopic imaging they could revealed underlying complex structures of the see-through organs at the cellular level. Resulting organ maps can serve as templates for 3D-bioprinting technologies. In the future, ...

DNA repair: Opening the hatch to heal the break

05-Sep-2019 - LMU researchers have determined the structure of a key enzyme complex that is involved in DNA repair, and traced the cycle of conformational changes that it undergoes while performing its biochemical function. Various types of DNA damage can have serious repercussions, both for the individual ...

Tiny “blinkers” reveal molecules inside cells

18-Mar-2019 - LMU physicists led by Ralf Jungmann introduce an entirely new approach to super-resolution microscopy: Tiny ‘blinkers’ enable simultaneous imaging of multiple biomolecules. In everyday life, blinking lights can send signals – for example, that a car is going to turn. Now, researchers have ...

Bacterial adhesion in vitro and in silico

How does a widespread bacterial pathogen adhere to tissues?

03-Apr-2018 - Bacterial pathogens have evolved highly effective strategies that enable them to adhere to target cells and niches in the tissues of their host organisms. As demonstrated, they even make use of relatively unfamiliar physical principles. In collaboration with scientists at the University of ...