Predicting the mode of action of new anti-cancer drugs with AI

Acceleration of the development of new cancer drugs

22-Nov-2024 - Plants, fungi and bacteria produce a variety of active substances that alter cell metabolism, sometimes to the point of cell death. This makes them promising candidates for new drugs against cancer and other diseases. Although a diverse range of bioactives exists, the further development of new ...

Evotec, Inserm, Lille University Hospital and Inserm Transfert enter collaboration

Identification of novel therapeutic targets in obesity and metabolic diseases

31-May-2024 - Evotec SE announced that the Company entered a partnership with Inserm, the French National Institute of Health and Medical Research, Lille University Hospital and Inserm Transfert (the private subsidiary of Inserm) to identify novel therapeutic targets and diagnostic and prognostic markers in ...

Using metabolomics for assessing safety of chemicals may reduce the use of lab rats

"We hope that learnings from this research will be included in new guidance for the chemical industry to allow commercial laboratories to provide these services widely"

26-Feb-2024 - Scientists have discovered a more robust way of grouping chemicals and using read-across for toxicological data to meet regulatory requirements, which could greatly reduce animal testing. The safety of chemicals is taken incredibly seriously by regulators and as such industry must meet certain ...

BASF to research on alternatives to animal testing on behalf of the European Chemicals Agency

Number of animal experiments required for safety assessments of chemical substances to be further reduced

07-Feb-2024 - The European Chemicals Agency (ECHA) has contracted a consortium that includes BASF to conduct scientific studies on the reliability and relevance of New Approach Methodologies (NAMs) as alternatives to animal testing and to promote the use of such methods in the future. The aim of the contract ...

Inflammation Values by Spectrometry

Quantifying acute-phase inflammation proteins by NMR

27-Jul-2023 - The analysis of all small molecules in an organism (the metabolome) has huge potential for medical diagnostics. A German research team is investigating this with nuclear magnetic resonance spectrometry (NMR). In a study recently published in Angewandte Chemie, they quantified acute-phase proteins ...

Bruker Acquires Prolab Instruments

Augment Multiomics Solutions

20-Jan-2022 - Bruker Corporation announced the acquisition of Prolab Instruments GmbH, a Swiss technology company specialized in low-flow, high precision liquid chromatography technology and systems. Financial terms of the transaction were not disclosed. Mr. Werner Doebelin, the Founder and CEO of Prolab, ...

Lifespin secures bridge financing

Artificial intelligence to determine health status and diagnose diseases

18-Jan-2022 - Lifespin GmbH in BioPark Regensburg has successfully concluded bridge financing to a total of € 2.5 million. The diagnostic data company is working successfully on an AI-based health platform that can measure important metabolic parameters in patients and expects to start series A in the funding ...

Red yeast from deep-sea sediment shows anticancer and antibacterial properties

On the trail of active ingredients from marine yeasts

21-Jan-2021 - Numerous natural products are awaiting discovery in all kinds of natural habitats. Especially microorganisms such as bacteria or fungi are able to produce diverse natural products with high biomedical application potential in particular as antibiotics and anticancer agents. This includes the ...

New pathways found for biotechnological degradation of industrial waste

Microorganism breaks down phenol under extreme conditions

19-Jan-2021 - Scientists led by Dr Meina Neumann-Schaal of the Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures GmbH in Braunschweig, Lower Saxony, have characterised the breakdown of phenol by Saccharolobus solfataricus. Using methods from the fields of metabolomics and ...

Key player in cell metabolism identified

18-Jan-2018 - Researchers from the Genomic Instability and Cancer Laboratory at Institute for Research in Biomedicine (IRB Barcelona) have identified a key role for EXD2 in protein production in the mitochondria, the cellular organelles responsible for the majority of energy generation. "We have provided ...