A New Approach for Diabetes Therapies: Inceptor Regulates Insulin Homeostasis

From Lab to Practice: A Start-up for New Diabetes Therapies

02-Dec-2024 - In 2021, a research team led by Prof. Heiko Lickert from Helmholtz Munich discovered the insulin-inhibitory receptor "Inceptor" and its role as a suppressor of the insulin signaling pathway. Now, the researchers have unlocked another, even more significant function of the receptor: it binds ...

Father's Diet Before Conception Influences Children's Health

Father's body weight influences the weight of the children and their susceptibility to metabolic diseases

07-Jun-2024 - A recent study conducted by Helmholtz Munich and the German Center for Diabetes Research provides new insights into how fathers' diets and overweight can affect their children's health even before conception. The findings of the study can help develop preventive health measures for men wishing to ...

What Our Genetic Information Tells Us About Type 2 Diabetes Risk and Complications

Largest Study on Genetic Risk for Diabetes Now Published

21-Feb-2024 - The genetic information in our cells harbors secrets about the risks, progression, and complications of many diseases. With hundreds of millions of patients worldwide, identifying and understanding genetic risk for type 2 diabetes is of particular interest. In collaboration with an international ...

Diagnosis of Type 1 Diabetes After SARS-CoV-2 Infection

Researchers Find Possible Correlation

24-May-2023 - During the COVID-19 pandemic, an increase in the chronic autoimmune disease type 1 diabetes was observed in children, also in Germany. Researchers at Helmholtz Munich and TU Dresden, in cooperation with the Kassenärztliche Vereinigung Bayern (KVB), have now investigated whether there is a ...

When and why does type 1 diabetes manifest in children?

New findings on the development of the autoimmune disease in children

18-Oct-2022 - Study provides novel insights on dynamics of blood sugar levels and autoimmunity in early childhood: When and why does type 1 diabetes manifest in children? For the first time, researchers conducted a long-term study on infants and young children with increased genetic risk of type 1 diabetes. ...

Scientists Discover a Promising New Target for Diabetes Treatment

Research group has found a promising molecular target for beta cell protection and regeneration therapy that does not carry the unintended side effects of intensive insulin therapy

29-Jan-2021 - Researchers have discovered a novel and druggable insulin inhibitory receptor, named inceptor. The latest study from Helmholtz Zentrum München, the Technical University of Munich and the German Center for Diabetes Research is a significant milestone for diabetes research as the scientific ...

Beta cells from stem cells: Potential for cell replacement therapy

Quality control with CD177 can help save lots of time, efforts and money

29-Apr-2020 - The loss of insulin-secreting beta cells by autoimmune destruction leads to type 1 diabetes. Clinical islet cell transplantation has the potential to cure diabetes, but donor pancreases are rare. In a new study, a group of researchers developed an improved pluripotent stem cell differentiation ...

New drug combination restores beta cell function in animal model

Potential for diabetes remission

24-Feb-2020 - The loss of the identity of insulin-secreting beta cells in the islet of Langerhans, a process also called beta cell dedifferentiation, has been proposed to be a main reason for the development of diabetes. If and how dedifferentiated beta cells can be targeted by pharmacological intervention for ...

Looking at the good vibes of molecules: a new method for label-free metabolic imaging

09-Jan-2020 - Label-free dynamic detection of biomolecules is a major challenge in live-cell microscopy. The simultaneous visualization of dynamic alterations for classes of metabolites, such as carbohydrates and lipids, was an unmet need in biomedical research. Now, a novel imaging method developed by a ...

What and how much we eat might change our internal clocks and hormone responses

08-Nov-2019 - For the first time, a study led by researchers at Helmholtz Zentrum München and the German Center for Diabetes Research (DZD) shows how glucocorticoid hormones, such as cortisol, control sugar and fat levels differently during day and night, feeding and fasting, rest and activity, over the course ...