Researchers can measure distances in molecules optically

MINFLUX microscopy allows the determination of distances within biomolecules using an optical microscope

15-Oct-2024 - A team led by physicists Steffen Sahl and Stefan Hell at the Max Planck Institute for Multidisciplinary Sciences in Göttingen and the Max Planck Institute for Medical Research in Heidelberg has succeeded in measuring distances within biomolecules using a light microscope, down to one nanometer ...

ONE microscopy: from molecule to 3D structure with conventional microscopy

The simple and cost-effective method developed using a few simple but effective tricks

11-Oct-2024 - Researchers at the University Medical Center Göttingen (UMG) have developed a new method that makes it possible for the first time to image the three-dimensional shape of proteins with a conventional microscope. Combined with artificial intelligence, One-step Nanoscale Expansion (ONE) microscopy ...

Global guidelines to improve the quality of microscopy images in scientific publications

21-Sep-2023 - As part of a global initiative, researchers have drawn up guidelines for the publication of microscopy images in scientific outlets. The criteria, summarized in the form of checklists, form the basis for ensuring that published images in the field of life sciences and medicine are intelligible ...

WildDISCO: Visualizing Whole Bodies in Unprecedented Detail

AI Integration: Predicting Disease Progression Without the Use of Animal Models in Research

12-Jul-2023 - Researchers developed a new method called wildDISCO that uses standard antibodies to map the entire body of an animal using fluorescent markers. This revolutionary technique provides detailed 3D maps of structures, shedding new light on complex biological systems and diseases. WildDISCO has the ...

Scallop Eyes as Inspiration for New Microscope Objectives

New lens can be produced much more cheaply and offers equivalent or even better image quality than conventional lenses

04-Apr-2023 - Neuroscientists at the University of Zurich have developed innovative objectives for light microscopy by using mirrors to produce images. Their design finds correspondence in mirror telescopes used in astronomy on the one hand and the eyes of scallops on the other. The new objectives enable ...

New insights into the utilization of nanotechnology-based drugs

How nanoparticles get inside cells and release drugs

24-Jan-2023 - Novel drugs, such as vaccines against covid-19, among others, are based on drug transport using nanoparticles. Whether this drug transport is negatively influenced by an accumulation of blood proteins on the nanoparticle’s surface was not clarified for a long time. Scientists at the Max Planck ...

ZEISS microscope developers win the Deutscher Zukunftspreis 2022

The development of the ZEISS Lattice Lightsheet 7 for the gentle 3D imaging of living cells was honored with the Federal President's Award for Technology and Innovation

28-Oct-2022 - The President of Germany, Frank-Walter Steinmeier, awarded the Deutscher Zukunftspreis 2022, The Federal President's Award for Technology and Innovation, to the team from ZEISS during a festive ceremony. The jury recognized the ZEISS experts Dr. Thomas Kalkbrenner, Dr. Jörg Siebenmorgen, and Ralf ...

Raman Microspectroscopy for Microbiology

Methodology can provide new insights into a variety of key topics in microbiology

17-Jan-2022 - Raman microspectroscopy is a fast and non-invasive technology to determine the chemical composition of living microorganisms in near real-time. Jürgen Popp, scientific director of the Leibniz Institute of Photonic Technology, together with an international team of expert scientists, describes the ...

How Cells Correctly Choose Active Genes

Formation of Transcription Factories Resembles Condensation of Liquids

09-Nov-2021 - It is essential for cells to control precisely which of the many genes of their genetic material they use. This is done in so-called transcription factories, molecular clusters in the nucleus. Researchers of Karlsruhe Institute of Technology (KIT), Friedrich-Alexander-Universität ...

New Insights into Kidney Disease with Tropical Frog Models

AI analyzes data from light-sheet microscopy

09-Nov-2021 - Using cutting-edge genetic engineering, UZH researchers have developed a model to study hereditary kidney disease with the help of tropical frogs. The method allows them to collect large amounts of data on anomalies, which can then be analyzed using artificial intelligence. The research opens up ...