Water-shy proteins weaken protection against cancer

Special mutations in important protective proteins lead to the proteins being broken down longer and therefore faster

31-Oct-2024 - Cancer researchers at the Faculty of Medicine at the University of Freiburg have discovered that certain "non-stop mutations" make important protective proteins against cancer in the body longer, making them "water-shy". The proteins then become more unstable in the aqueous environment of the ...

Antibiotics highjack bacterial immunity

Molecular defense system protects bacteria from viruses and at the same time makes them susceptible to antibiotics

23-Jan-2024 - Bacteria have an immune system that protects them against viruses known as bacteriophages. A research team from the Universities of Tübingen and Würzburg has now shown how this immune system enhances the effect of specific antibiotics against the cholera pathogen Vibrio cholerae. The immune ...

Neuromuscular 2D model for drug research

21-Dec-2023 - In neuromuscular diseases, the interaction between neurons and muscle cells is disrupted. Researchers led by Mina Gouti are now able to simulate this in 2D in a culture dish. The approach is well suited for high-throughput screening in drug research, they write in Nature Communications. Around ...

DESY X-ray lightsource identifies promising candidates for COVID drugs

Existing active substances bind to key virus protein

07-Apr-2021 - A team of researchers has identified several candidates for drugs against the coronavirus SARS-CoV-2 at DESY´s high-brilliance X-ray lightsource PETRA III. They bind to an important protein of the virus and could thus be the basis for a drug against Covid-19. In a so-called X-ray screening, the ...

Looking for a needle in a haystack

TU Dresden's BIOTEC and its PharmAI spin-off analyse millions of active substances that could cure Covid-19

20-Jul-2020 - The goal: Identify new drugs for Covid-19 therapy in the fastest possible way, conduct clinical tests and win the battle against the virus. The method: A large-scale research competition that screens billions of molecules in order to find those blocking interactions on SARS-CoV-2, identifying ...

Proteros and University of Cincinnati, Drug Discovery Center establish collaboration to offer high-throughput screening services

15-Mar-2011 - Proteros Biostructures GmbH announced that it has entered into an agreement with University of Cincinnati, Drug Discovery Center (UC DDC), under which Proteros will provide biotech and pharmaceutical companies with access to UC DDC’s ultra-high-throughput and high-content screening platform ...