Keeping herpes in check

Synthetic heparanase inhibitors inhibit the spread of herpes viruses in tissue

11-Sep-2023 - Herpes is not only unpleasant but it can, in some cases, also have dangerous complications and life-threatening consequences. In the journal Angewandte Chemie, a research team has now introduced a completely new approach for treating herpes. Their method is based on the inhibition of an enzyme ...

Studying herpes encephalitis with mini-brains

“This model is now much closer to reality for the herpes virus than what has been used previously”

27-Jun-2023 - The herpes simplex virus-1 can sometimes cause a dangerous brain infection. Combining an anti-inflammatory and an antiviral could help in these cases, report scientists with the Rajewsky and Landthaler labs and the Organoid Platform at the Max Delbrück Center in “Nature Microbiology.” About 3.7 ...

Herpes virus to be weaponized to fight cancer

Viral immunotherapy could also prove effective against metastases

03-Jun-2022 - Viruses can make animals and humans sick – or healthy: Researchers at the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB have succeeded in genetically modifying the herpes simplex virus type 1, which triggers painful cold sores, in such a way that it can be used in the ...

Herpes virus decoded using new methods

A comprehensive systems biological analysis of the herpes virus genome has caused some surprises

30-Apr-2020 - The genome of the herpes simplex virus 1 was decoded using new methods. Hundreds of previously unknown gene products were found. The virus causes lip herpes, but can also be life-threatening. Until now, scientists had assumed that there are about 80 so-called open reading frames (ORFs) in the ...

Unique new antiviral treatment made using sugar

31-Jan-2020 - New antiviral materials made from sugar have been developed to destroy viruses on contact and may help in the fight against viral outbreaks. This new development from a collaborative team of international scientists shows promise for the treatment of herpes simplex (cold sore virus), respiratory ...

Neanderthals may have been infected by diseases carried out of Africa by humans

12-Apr-2016 - A new study suggests that Neanderthals across Europe may well have been infected with diseases carried out of Africa by waves of anatomically modern humans, or Homo sapiens. As both were species of hominin, it would have been easier for pathogens to jump populations, say researchers. This might ...

Your viruses could reveal your travel history, and more

05-Apr-2016 - The genomes of two distinct strains of the virus that causes the common lip cold sore, herpes simplex virus type 1 (HSV-1), have been identified within an individual person -- an achievement that could be useful to forensic scientists for tracing a person's history. The research also opens the ...

Nanoparticles to deliver vaccines to lungs

27-Sep-2013 - Many viruses and bacteria infect humans through mucosal surfaces, such as those in the lungs, gastrointestinal tract and reproductive tract. To help fight these pathogens, scientists are working on vaccines that can establish a front line of defense at mucosal surfaces. Vaccines can be delivered ...

AiCuris: No Resistant Herpes Simplex Virus (HSV) Observed in Phase II Trial with Herpes Drug AIC316

08-Sep-2011 - AiCuris announces that it will present the results of the resistance analysis from the recently completed phase II clinical trial with AIC316 at the 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in USA, Chicago. AIC316 is one of AiCuris lead compounds and was ...

AiCuris’ Novel HSV Compound AIC316 Shows Efficacy in Phase II

20-Jul-2011 - Phase II results for AiCuris' novel non-nucleosidic herpes simplex virus (HSV) inhibitor AIC316 reveal safety and efficacy in persons with genital herpes. The data were presented at the 19th ISSTDR Meeting (International Society for Sexually Transmitted Diseases Research) in Quebec, Canada, by ...