Unforeseen new drug target discovered for acute myeloid leukemia

29-Nov-2017 - A study has found an unexpected new drug target for acute myeloid leukaemia (AML) that could open new avenues to develop effective treatments against this potentially lethal disease. Researchers from the Wellcome Trust Sanger Institute, the Gurdon Institute and their collaborators show that ...

Cornell: Project aims to sequence 2,500 genomes

Cornell plays key role in developing most detailed map of human DNA variation

03-Nov-2010 - Cornell researchers are part of an international collaboration to build the most detailed map of human genetic variation. The map promises to provide a much more comprehensive understanding of the role of inherited DNA variation in human history, evolution and disease and the best methods to use ...

First genetic link to common migraine exposed

Genetic variant may increase susceptibility to migraine triggers

31-Aug-2010 - A world-wide collaboration of researchers has identified the first-ever genetic risk factor associated with common types of migraine. The researchers, who looked at the genetic data of more than 50,000 people, have produced new insights into the triggers for migraines attacks and they hope their ...

Unraveling kidney cancer

Mutations in the genome regulation machinery identified in clear cell renal cell carcinoma

11-Jan-2010 - In a new study, scientists have searched for mutations in the gene regions of more than 100 kidney cancer samples, the largest number of samples from a single tumour type to be sequenced to date. Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer, with 102,000 deaths ...

Researchers find human protein that prevents H1N1 influenza infection

21-Dec-2009 - Howard Hughes Medical Institute researchers have identified a naturally occurring human protein that helps prevent infection by H1N1 influenza and other viruses, including West Nile and dengue virus. A research team led by Howard Hughes Medical Institute investigator Stephen J. Elledge and his ...

Scientists reveal malaria parasites' tactics for outwitting our immune systems

03-Dec-2009 - Malaria parasites are able to disguise themselves to avoid the host's immune system, according to research funded by the Wellcome Trust and published in Proceedings of the National Academy of Sciences. The malaria parasite infects healthy red blood cells, where it reproduces. The P. falciparum ...

Biology of emergent Salmonella exposed

03-Dec-2009 - Researchers have characterised a new multi drug resistant strain of Salmonella Typhimurium that is causing life-threatening disease in Africa. This type of Salmonella bug normally causes diarrhoea and is rarely fatal. The new strain infects vulnerable children and adults in many regions of ...

Jumping genes, gene loss and genome dark matter

New map of copy number variation in the human genome is a resource for human genetics

09-Oct-2009 - In research published by Nature, an international team describes the finest map of changes to the structure of human genomes and a resource they have developed for researchers worldwide to look at the role of these changes in human disease. They also identify 75 'jumping genes' - regions of our ...

Scientists decode genome of deadly parasitic worm

21-Jul-2009 - Scientists have sequenced the genome of the parasite that causes intestinal schistosomiasis (also known as bilharzia or snail fever), a devastating tropical disease that afflicts more than 200 million people in the developing world. Najib El-Sayed, associate professor in the University of ...

Novel method to reveal drug targets

Interactions between proteins studied on a global scale

25-Feb-2008 - Wellcome Trust Sanger Institute scientists have developed a new large-scale method to identify the interactions between proteins that are a major target for therapeutic intervention. The novel method can identify the weak, short-lived interactions that are characteristic of cell responses to cues ...