Father's Diet Before Conception Influences Children's Health

Father's body weight influences the weight of the children and their susceptibility to metabolic diseases

07-Jun-2024 - A recent study conducted by Helmholtz Munich and the German Center for Diabetes Research provides new insights into how fathers' diets and overweight can affect their children's health even before conception. The findings of the study can help develop preventive health measures for men wishing to ...

Node-centric expression models (NCEMs): Graph-neural networks reveal communication between cells

01-Nov-2022 - How do single cells communicate in a tissue? How can these interactions be modeled, while retaining information of spatial context? Researchers around Fabian Theis from Helmholtz Munich Computational Health Center and Technical University of Munich (TUM) have generated a new method to represent ...

Predicting cell fates

Researchers develop AI solutions for next-gen medical research

03-Feb-2022 - Data is not only the answer to numerous questions in the business world; the same applies to biomedical research. In order to develop new therapies or prevention strategies for diseases, scientists need more and better data, faster and faster. However, the quality is often very variable and the ...

Revealing the secrets of cell competition

Which features distinguish “winner” from “loser” cells

23-Jul-2021 - Cellular competition is a crucial quality control process that ensures that the development of an organism relies on healthy cells. Researchers revealed the secrets underlying cell competition and what features can pre-determine whether a cell will survive or not. Defects in energy production are ...

Sars-Cov-2 infects cells via specific viral entry factors that are more abundant in elderly, men and smokers

This could partially explain the differences of COVID-19 severity reported in relation to age, gender and smoking status

19-Mar-2021 - A new study uncovers which cell types can be infected by SARS-CoV-2 due to their viral entry factors. The study also suggests that increased gene expression of these viral entry factors in some individuals partially explains the differences of COVID-19 severity reported in relation to age, gender ...

New software processes huge amounts of single-cell data

Comprehensive analysis of large gene-expression datasets

13-Feb-2018 - Scientists from the Helmholtz Zentrum München have developed a program that is able to help manage enormous datasets. The software, named Scanpy, is a candidate for analyzing the Human Cell Atlas. “It’s about analyzing gene-expression data of a large number of individual cells,” explains lead ...